Results 111 to 120 of about 12,305 (169)

Effect of VDR knockout on cerebral malaria.

, 2012
(A) The percent of B6 and B6.VDR−/− P. berghei ANKA infected mice that survived over time is given in Kaplan-Meier curves. Death was defined as a parasitemia ≥60%, moribundity or death (P = 0.38).
Brandi K. Vickers (189190), Michael Waisberg (32834), Stephanie B. Yager (189193), Susan K. Pierce (189199), Christina K. Lin (189195)   +4 more
core   +1 more source

NFкB pathway suppression as a key driver of pacritinib response in high‐risk myelofibrosis

British Journal of Haematology, EarlyView.
R. Van Dijck, M. ter Borg, B. van der Holt, A. E. C. Broers, M. D. Hazenberg, J. J. Cornelissen, N. P. M. Schaap, E. de Pater, P. A. W. te Boekhorst   +8 more
wiley   +1 more source

Feasibility of lattice radiation therapy using a noncoplanar vertex arrangement and dynamic conformal arcs

Journal of Applied Clinical Medical Physics, Volume 27, Issue 10, October 2026.
Abstract Background Current Lattice radiation therapy (LRT) mainly uses inverse IMRT/VMAT optimization, which is time‐consuming and complex; however the high modulation complexity compromises dosimetric accuracy and blurs the peak‑to‑valley dose ratio.
Haixia Cui, Wei Huang, Xin Yi, Wenli Lu, Qingfeng Jiang   +4 more
wiley   +1 more source

Coactivator-independent vitamin D receptor signaling causes severe rickets in mice, that is not prevented by a diet high in calcium, phosphate, and lactose

Bone Research
The vitamin D receptor (VDR) plays a critical role in the regulation of mineral and bone homeostasis. Upon binding of 1α,25-dihydroxyvitamin D3 to the VDR, the activation function 2 (AF2) domain repositions and recruits coactivators for the assembly of ...
Stefanie Doms, Lieve Verlinden, Iris Janssens, Justine Vanhevel, Roy Eerlings, René Houtman, Shigeaki Kato, Chantal Mathieu, Brigitte Decallonne, Geert Carmeliet, Annemieke Verstuyf   +10 more
doaj   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Increased expression of VDR in thicker melanoma

, 2016
Vitamin D and vitamin D receptor (VDR) can enhance or suppress the transcription of key genes involved in the regulation of cell growth. However, in the literature it has been reported only few data on the rate of VDR expression in melanoma (MM ...
D. Didona, G. Paolino, C. Panetta, C. Di Mattia, E. Moliterni, G. De Vita, P. Donati, S. Calvieri, C. Cota, M. Picardo   +9 more
core  

VDR expression is CYP24A1-dependent and vice-versa CYP24A1 expression is VDR dependent.

, 2012
(A, B and C) CYP24A1 and VDR protein expression analysis by western blotting 4 days after transfection with siRNAs scrambled (control), siCYP24A1, siVDR or pCMV-CYP24A1 ...
Paul Xing (125022), René St-Arnaud (125040), Frédrick Charbonneau (125018), Guy Rousseau (125035), Rania Boukrab (125030), Marie-Luise Brezniceanu (125045), Alexandre Tourigny (125012)   +6 more
core   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

Effect of Zinc Oxide Nanoparticles From Infant Formula Milk Powder on Colon Cells In Vitro

Journal of Applied Toxicology, Volume 46, Issue 10, Page 3437-3445, October 2026.
ABSTRACT Zinc is an essential trace element that participates in numerous metabolic processes; however, excessive exposure may interfere with the absorption of other metals, such as copper. In recent years, nanotechnology has experienced rapid growth, and zinc oxide nanoparticles (ZnO NPs) have garnered significant attention due to their versatile ...
Gloria Salinas‐Lucero, Karla Juarez‐Moreno, Rafael Vazquez‐Duhalt   +2 more
wiley   +1 more source

Hyperandrogenemia impairs endometrial vitamin D receptor expression in polycystic ovary syndrome

Gynecological Endocrinology
Objectives To determine the effects of hyperandrogenemia and other phenotypic parameters on endometrial vitamin D receptor (VDR-X2 and VDR-X4) expression in women with polycystic ovary syndrome (PCOS) undergoing ovarian stimulation and total embryo ...
Nur D. Gungor, Onder Celik, Ulun Ulug, Nilufer Celik, Aynur Ersahin, Kagan Gungor, Arzu Yurci, Meltem Yardim, Murat Kobaner, Ahmet Tektemur, Tuncay Kuloglu, Ivan Ilkov, Maslarski, Sudenaz Celik, Cevdet Duran   +13 more
doaj   +1 more source