Results 101 to 110 of about 25,428 (209)

Ein photoschaltbares Vitamin‐D‐Mimetikum mit agonistischer und antagonistischer Aktivität ermöglicht bidirektionale optische Kontrolle von VDR

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Vitamin D entfaltet über die Aktivierung des ligandenabhängigen Transkriptionsfaktors Vitamin‐D‐Rezeptor (VDR) komplexe und zellspezifische biologische Wirkungen in verschiedenen Geweben. Das photoschaltbare Vitamin‐D‐Mimetikum 10 wechselt durch Belichtung zwischen VDR‐Antagonisten‐ (E) und Agonisten‐Aktivität (Z) und bietet eine bislang einzigartige ...
Xiu Ge, Sabine Willems, Francesco Melfi, Tufan Mukhopadhyay, Johannes Morstein, Jordan Artzy, Loris Knümann, Giorgia Sbriccoli, Jörg Pabel, Julian A. Marschner, Dirk Trauner, Daniel Merk   +11 more
wiley   +1 more source

An Agonist/Antagonist Photo‐Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDR

Angewandte Chemie International Edition, Volume 65, Issue 29, 13 July 2026.
Vitamin D exhibits complex and cell‐specific biological effects in multiple tissues via activation of the ligand‐sensing transcription factor vitamin D receptor (VDR). The photo‐switchable vitamin D mimetic 10 transitions between VDR antagonist (E) and agonist (Z) activity upon illumination and offers unprecedented bidirectional optical control over ...
Xiu Ge, Sabine Willems, Francesco Melfi, Tufan Mukhopadhyay, Johannes Morstein, Jordan Artzy, Loris Knümann, Giorgia Sbriccoli, Jörg Pabel, Julian A. Marschner, Dirk Trauner, Daniel Merk   +11 more
wiley   +1 more source

VDR promotes pancreatic cancer progression in vivo by activating CCL20-mediated M2 polarization of tumor associated macrophage

Cell Communication and Signaling
Background Activation of VDR pathway was a promising anti-tumor therapy strategy. However, numerous clinical studies have demonstrated the effect of activating VDR is limited, which indicates that VDR plays a complex role in vivos.
Hengzhen Li, Yuli Ruan, Chao Liu, Xiaona Fan, Yuanfei Yao, Yisheng Dai, Yushuai Song, Dan Jiang, Ning Sun, Guangtao Jiao, Zhuo Chen, Shiheng Fan, Fanfei Meng, Huike Yang, Yanqiao Zhang, Zhiwei Li   +15 more
doaj   +1 more source

Candida oesophagitis as an Initial Manifestation of VEXAS Syndrome: Expanding Evidence for an Acquired Immunodeficiency Phenotype

eJHaem, Volume 7, Issue 4, August 2026.
Demi Rianne Vintges, Marina Weerheim, Faiz Karim   +2 more
wiley   +1 more source

Vitamin D receptor induces oxidative stress to promote esophageal squamous cell carcinoma proliferation via the p53 signaling pathway

Heliyon
Background: Esophageal squamous cell carcinoma (ESCC) is a common pathological esophageal cancer with poor prognosis. Vitamin D deficiency reportedly occurs in ESCC patients, and this is related to single nucleotide polymorphism of vitamin D receptor ...
Qi-Xin Shang, Yu-Shang Yang, Han-Lu Zhang, Ya-Ping Cheng, Han Lu, Yong Yuan, Long-Qi Chen, Ai-Fang Ji   +7 more
doaj   +1 more source

Otistik bozukluklu çocuk hastalarda VDR gen polimorfizmi, VDR gen ekspresyonu ve VDR geni promotor metilasyonunun araştırılması

, 2020
Yaygın gelişimsel bozukluklar (YGB) içinde sınıflandırılan Otistik Bozukluk (OB), yaşamın ilk yıllarında başlayan, sosyal beceri, sözel ve sözel olmayan iletişim, bilişsel gelişimde özgül gecikmeler ve sapmalar, tekrarlayacı ve basmakalıp davranışlarla karakterize nöropsikiyatrik bozukluktur. OB ile ilgili tanımlanmış çok sayıda lokusta mutasyon, kopya
openaire   +1 more source

VDR Gene [PDF]

, 2020
openaire   +1 more source

Relationship between VDR Gene Polymorphism and Renal Osteodystrophy in Persistent Hemodialysis Patients

Linchuang shenzangbing zazhi, 2018
Objective To investigate the relationship between VDR gene polymorphism and bone mineral density( BMD) in patients undergoing maintenance hemodialysis by analyzing the changes in vitamin D receptor( VDR) gene polymorphism.
ZHANG Xin, WANG Xiao-hui, HE Yong, YANG Guo-sheng, PENG Qing-ping   +4 more
doaj  

Diurnal vasopressor variation in critically ill adults. [PDF]

J Anesth Analg Crit Care
Kahn MR, Klinhom C, Adili A, Wilson ML, Chang DW, Huerta LE.   +5 more
europepmc   +1 more source

Vitamin D receptor signaling in inflammatory senescence-associated skin aging: Mechanisms and therapeutic potentials. [PDF]

J Cell Commun Signal
Guan L, Yang F, Li M, Chen Y, Zhao Z, Li H, Luo D, Li Q, Chen Y.   +8 more
europepmc   +1 more source