Results 131 to 140 of about 182,452 (358)

Patterns of spatial genetic structures in Aedes albopictus (Diptera: Culicidae) populations in China. [PDF]

, 2019
BACKGROUND:The Asian tiger mosquito, Aedes albopictus, is one of the 100 worst invasive species in the world and the vector for several arboviruses including dengue, Zika and chikungunya viruses.
Fan, Peiyang, He, Yulan, Song, Zhangyao, Wang, Jiatian, Wei, Yong, Yang, Dizi, Zheng, Xueli, Zheng, Zihao, Zhong, Daibin, Zhou, Guofa   +9 more
core  

Vector-borne diseases in Brazil: climate change and future warming scenarios

, 2020
Bruno Moreira de Carvalho, Letícia Palazzi Perez, Beatriz Fátima Alves de Oliveira, Ludmilla da Silva Viana Jacobson, Marco Aurélio Pereira Horta, Andréa Sobral de Almeida, Sandra de Souza Hacon   +6 more
openalex   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach [PDF]

, 2022
Kimberly Fornace, Benny Obrain Manin, Jason Matthiopoulos, Heather M. Ferguson, Chris Drakeley, Kamruddin Ahmed, Koay Teng Khoon, Robert M. Ewers, Sylvia Daim, Tock H. Chua   +9 more
openalex   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Single-cell transcriptomics unveils molecular signatures of neuronal vulnerability in a mouse model of prion disease that overlap with Alzheimer’s disease

Nature Communications
Understanding why certain neurons are more sensitive to dysfunction and death caused by misfolded proteins could provide therapeutically relevant insights into neurodegenerative disorders.
Jessy A. Slota, Lise Lamoureux, Kathy L. Frost, Babu V. Sajesh, Stephanie A. Booth   +4 more
doaj   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

CLIMATE CHANGE AND VECTOR-BORNE DISEASES IN SOUTHERN EUROPE [PDF]

, 2013
Vector-borne infections have always caused suffering throughout the history. Thealliance of arthropods and microorganisms is hard to defeat as insecticides anddrugs proved to be temporary solutions.
Kaya Sami Nizamoglu
core  

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Climate change and vector-borne diseases: a multi-omics approach of temperature-induced changes in the mosquito [PDF]

, 2023
Rachel Bellone, P Lechat, Laurence Mousson, Valentine Gilbart, Géraldine Piorkowski, Chloé Bohers, Andres Merits, Étienne Kornobis, Julie Réveillaud, Christophe Paupy, Marie Vazeille, Jean-Philippe Martinet, Yoann Madec, Xavier de Lamballerie, Catherine Dauga, Anna‐Bella Failloux   +15 more
openalex   +1 more source