Results 141 to 150 of about 182,452 (358)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

A goatpox but not sheeppox heterologous live attenuated vaccines provide complete protection against lumpy skin disease in cattle under experimental conditions

Scientific Reports
Homologous vaccination has proven to be an effective tool to control and eradicate lumpy skin disease. However, their use has been met with some trepidation for diverse reasons, in some regions, and has resulted in the use of heterologous vaccines ...
Andy Haegeman, Wannes Philips, Laurent Mostin, Ilse De Leeuw, Willem Van Campe, Claude Saegerman, Kris De Clercq, Nick De Regge   +7 more
doaj   +1 more source

Heartwater surveillance in Guadeloupe: a model of partnership between research and surveillance for the Caribbean [PDF]

, 2012
Heartwater, a tick-borne disease of ruminants transmitted by Amblyomma ticks is present in 3 Caribbean islands: Guadeloupe, Marie-Galante and Antigua, representing a threat for neighboring islands and North America.
Faverjon, Céline, Gerbier, Guillaume, Laurent, Marion, Lefrançois, Thierry, Pradel, Jennifer, Redon, Jean-Marc, Teissier, R., Vachiery, Nathalie   +7 more
core  

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

Improve the Capacities of Zimbabwe for the Control of animal and zoonotic diseases [PDF]

, 2019
The main objective of the CAZCOM project is to build Zimbabwe's capacity to improve the surveillance and control of important animal and zoonotic diseases.
Bourgarel, Mathieu, De Nys, Hélène, Guerrini, Laure, Liégeois, Florian, Makaya, Pious V., Matope, Gift, Pfukenyi, Davies Mubika   +6 more
core  

Theoretical formulation for mosquito host-feeding patterns : Application to a west nile virus focus of Southern France

, 2011
Host-feeding patterns play a key role in the transmission of vector-borne diseases such as West Nile fever, which involves two kinds of vertebrates, birds and mammals. In this study, we propose a theoretical formulation for mosquito host-feeding patterns
Balenghien, Thomas, Bicout, Dominique, Fouque, Florence, Sabatier, Philippe   +3 more
core   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

A novel approach for predicting risk of vector-borne disease establishment in marginal temperate environments under climate change: West Nile virus in the UK

, 2021
David A. Ewing, Bethan V. Purse, Christina A. Cobbold, Steven M. White   +3 more
openalex   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

GIS in vector borne diseases [PDF]

, 2010
Guy Hendrickx
core   +1 more source