Results 181 to 190 of about 2,059,233 (272)

The Novel Viral Non‐Coding RNA LMP2A‐IT1 Promotes the Lytic Replication of EBV

Advanced Science, EarlyView.
Decades after its discovery, EBV's genome still harbours unannotated “dark matter”. LMP2A‐IT1, a novel EBV‐encoded transcript identified in this work, is strongly upregulated during lytic replication and promotes BZLF1 expression, likely through activation of inflammatory responses, thereby enhancing viral propagation in a self‐reinforcing positive ...
Zheng‐Zhou Lu, Jun‐Fei Wu, Nannan Zhu, Ming‐Hui Yang, Le‐Le Zhang, Yuan‐Tao Liu, Wei‐Jun Chen, Jin‐Kun Tang, Jia‐Wei Ge, Chao‐Bo Lei, Tao Zhang, Yu Wang, Chao‐Yun Huang, Qian Zhong, Mu‐Sheng Zeng, Yan Li   +15 more
wiley   +1 more source

NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF‐κB Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated cachexia (CAC) is a devastating multifactorial syndrome characterized by progressive skeletal muscle atrophy. Its mechanisms remain incompletely clarified, with limited effective therapeutic targets. NUB1, a negative regulator of ubiquitin‐like proteins mediating protein degradation, has not been fully elucidated in CAC ...
Yuqi Han, Yaru Xia, Weiquan Li, Jiaming Wu, Tiexi Yu, Diaoyi Tan, Daojia Miao, Wen Li, Xuejiao Dong, Jiemin Li, Yu Jiao, Guixiao Huang, Xiaoping Zhang, Hongmei Yang   +13 more
wiley   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source

Forced displacements at the human-animal interface: a narrative review of knowledge gaps and One Health insights. [PDF]

Int Health
Casti G, Nair C, De Ponti E, Squillace F, Ceschi P.   +4 more
europepmc   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

MAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression

Advanced Science, EarlyView.
Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang, Zhigang Bai, Haibo Wang, Yu Guo, Yan Zhang, Meihan Hu, Shuaikang Fan, Ran Song, Tongmei Zhang, Mengqi Deng, Xiaomei Yang, Zhongtao Zhang, Junqi He   +12 more
wiley   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Anaplasma spp., Coxiella, Babesia and Theileria Infections in Vermipsylla Alakurt Fleas. [PDF]

Acta Parasitol
Jiushikun J, Yizigeleke T, Fan Y, Li W, Zhang Y, Zhao G, Tang L, Wang Y.   +7 more
europepmc   +1 more source

Delaying the Inevitable? U.S. Screwworm Closures and Feeder Cattle Market Dynamics

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Biosecurity trade restrictions are commonly framed as preventive measures, yet in many settings they function primarily as policies of delay: they impose immediate market costs while only postponing the arrival of biological risks. This paper evaluates that intertemporal tradeoff using the 2024–2025 US suspension of live cattle imports from ...
Shelby Sumner, Savannah Jones, Tania Islam, K. Aleks Schaefer   +3 more
wiley   +1 more source

Arthropod-Related Health Threats (ARHTs) and Nuisance Arthropods in North Khorasan Province, Iran: A Comprehensive Review. [PDF]

J Trop Med
Bakhshi H, Arzamani K, Shoraka H, Kouhestani F, Soltani A, Nejati J, Oskouei AO, Saghafipour A.   +7 more
europepmc   +1 more source