Results 71 to 80 of about 219,381 (279)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
On the obstruction to extending a vector bundle from a submanifold [PDF]
, 2022 A. V. Gavrilov
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Classification of quotient bundles on the Fargues-Fontaine curve
, 2019 We completely classify all quotient bundles of a given vector bundle on the Fargues-Fontaine curve. As consequences, we have two additional classification results: a complete classification of all vector bundles that are generated by a fixed number of ...
Hong, Serin
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Elliptic operators on refined Sobolev scales on vector bundles
Open Mathematics, 2017 We introduce a refined Sobolev scale on a vector bundle over a closed infinitely smooth manifold. This scale consists of inner product Hörmander spaces parametrized with a real number and a function varying slowly at infinity in the sense of Karamata. We
Zinchenko Tetiana
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
On a Lie Algebraic Characterization of Vector Bundles
Symmetry, Integrability and Geometry: Methods and Applications, 2012 We prove that a vector bundle π: E→M is characterized by the Lie algebra generated by all differential operators on E which are eigenvectors of the Lie derivative in the direction of the Euler vector field.
Pierre B.A. Lecomte +2 more
doaj +1 more source