Results 81 to 90 of about 2,190,858 (340)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Bacillus sphaericus exposure reduced vector competence of Anopheles dirus to Plasmodium yoelii by upregulating the Imd signaling pathway

Parasites & Vectors, 2020
Background Vector control with Bacillus sphaericus (Bs) is an effective way to block the transmission of malaria. However, in practical application of Bs agents, a sublethal dose effect was often caused by insufficient dosing, and it is little known ...
Shasha Yu, Pan Wang, Jie Qin, Hong Zheng, Jing Wang, Tingting Liu, Xuesen Yang, Ying Wang   +7 more
doaj   +1 more source

The Vector Model of Competence Diagnostics

Mediterranean Journal of Social Sciences, 2015
The article summarizes the results of the theoretical study of the problem of diagnostics designing that takes into account the multidimensional nature of competence. Competences aggregate inconsistent components. Therefore, in order to describe them, it is natural to apply the category of multidimensionality.
Andrei Viktorovich Dorofeev, Al'fiia Faizrakhmanovna Latypova   +1 more
openaire   +2 more sources

Secondary vectors of Zika Virus, a systematic review of laboratory vector competence studies

PLOS Neglected Tropical Diseases, 2023
Background After the unprecedented Zika virus (ZIKV) outbreak in the western hemisphere from 2015–2018, Aedes aegypti and Ae. albopictus are now well established primary and secondary ZIKV vectors, respectively. Consensus about identification and importance of other secondary ZIKV vectors remain. This systematic review aims to provide a list of vector
Marina Bisia, Carlos Alberto Montenegro-Quiñonez, Peter Dambach, Andreas Deckert, Olaf Horstick, Antonios Kolimenakis, Valérie R. Louis, Pablo Manrique‐Saide, Αntonios Michaelakis, Silvia Runge‐Ranzinger, Amy C. Morrison   +10 more
openaire   +5 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Vector competence of Aedes albopictus populations for chikungunya virus is shaped by their demographic history

Communications Biology, 2020
The mosquito Aedes albopictus is one of the most dangerous invasive species. Its worldwide spread has created health concerns as it is a major vector of arboviruses of public health significance such as chikungunya (CHIKV).
A. Vega-Rúa, M. Marconcini, Y. Madec, M. Manni, Davide Carraretto, L. Gomulski, G. Gasperi, A. Failloux, A. Malacrida   +8 more
semanticscholar   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Determining dengue infection risk in the Colombo district of Sri Lanka by inferencing the genetic parameters of Aedes mosquitoes

BMC Infectious Diseases
Background For decades, dengue has posed a significant threat as a viral infectious disease, affecting numerous human lives globally, particularly in tropical regions, yet no cure has been discovered.
Piyumi Chathurangika, Lakmini S. Premadasa, S. S. N. Perera, Kushani De Silva   +3 more
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source