Results 81 to 90 of about 147,779 (282)

Developing Genetic Tools for Geobacillus [PDF]

open access: yes, 2014
Bacillus and Geobacillus are the primary bacterium used in biotechnology industries due to their ability to excrete extracellular materials such as proteins, enzymes and other byproducts.
Artale, Brittany
core   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann   +17 more
wiley   +1 more source

Early signatures of regime shifts in gene expression dynamics

open access: yes, 2013
Recently, a large number of studies have been carried out on the early signatures of sudden regime shifts in systems as diverse as ecosystems, financial markets, population biology and complex diseases.
Bose, Indrani   +3 more
core   +1 more source

Influences on classification accuracy of exam sets: an example from vocational education and training [PDF]

open access: yes, 2012
Classification accuracy of single exams is well studied in the educational measurement literature. However, when making important decisions, such as certification decisions, one usually uses several exams: an exam set.
Eggen, T.J.H.M., Hubregtse, M.
core   +3 more sources

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

open access: yesAdvanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat   +11 more
wiley   +1 more source

N-linked glycosylation of the West Nile virus envelope protein is not a requisite for avian virulence or vector competence.

open access: yesPLoS Neglected Tropical Diseases, 2019
The N-linked glycosylation motif at amino acid position 154-156 of the envelope (E) protein of West Nile virus (WNV) is linked to enhanced murine neuroinvasiveness, avian pathogenicity and vector competence.
Payal D Maharaj   +11 more
doaj   +1 more source

Temporal Dynamics of ‘Ca. Phytoplasma mali’ Load in the Insect Vector Cacopsylla melanoneura

open access: yesInsects, 2020
The transmission of phytoplasmas is the result of an intricate interplay involving pathogens, insect vectors and host plants. Knowledge of the vector’s competence during its lifespan allows us to define more sustainable well-timed control strategies ...
Valentina Candian   +2 more
doaj   +1 more source

Weighting Scheme for a Pairwise Multi-label Classifier Based on the Fuzzy Confusion Matrix

open access: yes, 2018
In this work we addressed the issue of applying a stochastic classifier and a local, fuzzy confusion matrix under the framework of multi-label classification. We proposed a novel solution to the problem of correcting label pairwise ensembles.
Kurzynski, Marek, Trajdos, Pawel
core   +1 more source

Numerical cognition in bees and other insects [PDF]

open access: yes, 2016
The ability to perceive the number of objects has been known to exist in vertebrates for a few decades, but recent behavioral investigations have demonstrated that several invertebrate species can also be placed on the continuum of numerical abilities ...
Pahl, Mario, Si, Aung, Zhang, Shaowu
core   +1 more source

Home - About - Disclaimer - Privacy