Results 91 to 100 of about 3,256,056 (300)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Vector Control in Indonesia: Decentralization; Responsibility at Peripheric Level [PDF]

Pemberantasan vektor di Indonesia, suatu kebijaksanaan nasional yang melaksanakan penyemprotan rumah dengan DDT dewasa ini, banyak kendalanya. Menghadapi kendala tersebut, suatu kebljaksanaan baru telah diajukan, yaitu pemacuan suatu sistem survailans ...
Nalim, S. (Sustriayu)
core  

On the Optimal Control of the Free Boundary Problems for the Second Order Parabolic Equations. I.Well-posedness and Convergence of the Method of Lines [PDF]

We develop a new variational formulation of the inverse Stefan problem, where information on the heat flux on the fixed boundary is missing and must be found along with the temperature and free boundary.
Mezzan, Youness, Tber, Moulay Hicham
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hard Ticks as Vectors: The Emerging Threat of Tick-Borne Diseases in India

Pathogens
Hard ticks (Ixodidae) play a critical role in transmitting various tick-borne diseases (TBDs), posing significant global threats to human and animal health. Climatic factors influence the abundance, diversity, and vectorial capacity of tick vectors.
Nandhini Perumalsamy, Rohit Sharma, Muthukumaravel Subramanian, Shriram Ananganallur Nagarajan   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Metagenomic Analyses of Gut Bacteria of Two Sandfly Species from Western Ghats, India, Differing in Their Vector Competence for Leishmaniasis

Microorganisms
Phlebotomine sandflies are the primary vectors of Leishmania parasites, the causative agents of leishmaniasis. In India, Phlebotomus argentipes is the confirmed vector of Leishmania donovani.
Anns Tom, Nanda Kumar Yellapu, Manju Rahi, Prasanta Saini   +3 more
doaj   +1 more source

Spin vector control of a spinning space station [PDF]

Digital computer program simulates system and related functions. Program is intended for, but not limited to, altitude control studies of rotating space station.
Hendricks, T.
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

\u3ci\u3eDendroctonus Valens\u3c/i\u3e and \u3ci\u3eHylastes Porculus\u3c/i\u3e (Coleoptera: Scolytidae): Vectors of Pathogenic Fungi (Ophiostomatales) Associated With Red Pine Decline Disease. [PDF]

A study was conducted to determine whether Dendroctonus valens and Hylastes porculus could vector their commonly associated fungi to red pine. Field collected adult D.
Klepzig, Kier D, Raffa, Kenneth F, Smalley, Eugene B   +2 more
core   +1 more source