Results 71 to 80 of about 3,234,434 (300)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The finite-dimensional Witsenhausen counterexample

, 2009
Recently, a vector version of Witsenhausen's counterexample was considered and it was shown that in that limit of infinite vector length, certain quantization-based control strategies are provably within a constant factor of the optimal cost for all ...
Grover, Pulkit, Park, Se Yong, Sahai, Anant   +2 more
core   +5 more sources

Ticks (Argasidae and Ixodidae) in Tehran Province, Central Iran: Distribution and Seasonal Activity

Veterinary Medicine International
Ticks are obligatory ectoparasites of vertebrates and can transmit pathogens, including: arboviruses, bacteria, and parasites to humans and animals worldwide.
Mojtaba Beik-Mohammadi, Maryam Tavassoli, Zakkyeh Telmadarraiy, Hassan Vatandoost, Farrokh Dabiri   +4 more
doaj   +1 more source

Isolation of Borrelia miyamotoi and other Borreliae using a modified BSK medium

Scientific Reports, 2021
Borrelia spirochetes are the causative agents of Lyme borreliosis (LB) and relapsing fever (RF). Despite the steady rise in infections and the identification of new species causing human illness over the last decade, isolation of borreliae in culture has
Adam J. Replogle, Christopher Sexton, John Young, Luke C. Kingry, Martin E. Schriefer, Marc Dolan, Tammi L. Johnson, Neeta P. Connally, Kerry A. Padgett, Jeannine M. Petersen   +9 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Biological vector control with the sterile insect technique for the chilungunya disease [PDF]

, 2010
Chikungunya is a vector-borne Disease, usually localized in Asia and East-Africa, with Aedes albopictus mosquito as the principal vector for the Chikungunya virus.
Dumont, Yves, Tchuenche, J.M.
core  

12S rRNA based phylogeny and genetic diversity of Haemaphysalis spinigera, the primary vector for Kyasanur forest disease in India

Scientific Reports
Kyasanur Forest Disease (KFD), also known as Monkey Fever, is an important tick-borne viral infection in India. It is mainly transmitted by the hard tick vector, Haemaphysalis spinigera.
Nandhini Perumalsamy, Rohit Sharma, Ayyanar Elango, Shriram Ananganallur Nagarajan, Manju Rahi   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Acute undifferentiated febrile illness in a traveler returning from Burkina Faso, West Africa to Puducherry, India- a case report

BMC Infectious Diseases
Background Imported malaria remains a significant diagnostic challenge, particularly in regions approaching elimination. This case report is novel in its exploration of the complexities involved in diagnosing malaria imported from a high-endemic area to ...
Srikanth Srirama, Krishan Kumar Sihag, Anand Kumar Chandrasekaran, Neethi Prasannan Latha, Waseema Arif, Balaji Sampath Kumar, Panneer Devaraju   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source