Results 71 to 80 of about 11,411,963 (305)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Identification and prioritisation of potential vaccine candidates using subtractive proteomics and designing of a multi-epitope vaccine against Wuchereria bancrofti

Scientific Reports
This study employed subtractive proteomics and immunoinformatics to analyze the Wuchereria bancrofti proteome and identify potential therapeutic targets, with a focus on designing a vaccine against the parasite species.
Murali Aarthy, G. Navaneetha Pandiyan, R. Paramasivan, Ashwani Kumar, Bhavna Gupta   +4 more
doaj   +1 more source

Evaluation of MAGNet, a long-lasting insecticidal mosquito net against Anopheles fluviatilis in experimental huts in India

Malaria Journal, 2019
Background MAGNet LN is a wash resistant long-lasting insecticidal (polyethylene) net (LLIN) in which the alpha-cypermethrin insecticide is incorporated within the 150 denier high density polyethylene monofilaments of the nets. The bio-efficacy of MAGNet
Gunasekaran Kasinathan, Sudhansu Sekhar Sahu, Vijayakumar Tharmalingam, Subramanian Swaminathan, Manju Rahi, Jambulingam Purushothaman   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Spatial justice and health (in)equity: the case of vector-borne diseases

Humanities & Social Sciences Communications
From a spatial justice perspective, this article argues that the spatial plane is ‘constructed’ and that socio-spatial configurations can create and intensify health inequities for vulnerable sections. Employing a mixed methods design, the study inquired
Anoop C. Choolayil, Panneer Devaraju, Muhammed Jabir, Srikanth Srirama, Balaji Kumar, Vijayakumar Balakrishnan, Srividya Vissvesaran   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Disease Prevention Through Vector Control: Guidelines for relief organisations [PDF]

, 1995
The number of refugees and displaced persons has increased greatly in recent years. At least 80 per cent of them are living in tropical or semi-tropical countries where vector borne diseases, such as malaria, dengue, kala azar, sleeping sickness ...
Thomson, Madeleine C
core   +1 more source

Innovative sterile male release strategies for Aedes mosquito control: progress and challenges in integrating evidence of mosquito population suppression with epidemiological impact

Infectious Diseases of Poverty
Background Aedes mosquitoes pose a significant global threat as vectors for several debilitating arboviruses, including dengue, Zika, yellow fever, and chikungunya.
Arya Rahul, Appadurai Daniel Reegan, A. N. Shriram, Florence Fouque, Manju Rahi   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Insecticide Resistance and Vector Control [PDF]

Emerging Infectious Diseases, 1998
Insecticide resistance has been a problem in all insect groups that serve as vectors of emerging diseases. Although mechanisms by which insecticides become less effective are similar across all vector taxa, each resistance problem is potentially unique and may involve a complex pattern of resistance foci.
William G. Brogdon, Janet C. McAllister
openaire   +5 more sources