Results 71 to 80 of about 11,911,509 (308)

Transcriptomics and disease vector control [PDF]

BMC Biology, 2010
Next-generation sequencing can be used to compare transcriptomes under different conditions. A study in BMC Genomics applies this approach to investigating the effects of exposure to a range of xenobiotics on changes in gene expression in the larvae of Aedes aegypti, the mosquito vector of dengue fever.
Ranson Hilary, Vontas John, Alphey Luke
openaire   +4 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Malaria transmission after five years of vector control on Bioko Island, Equatorial Guinea. [PDF]

, 2012
BACKGROUND: Malaria is endemic with year-round transmission on Bioko Island. The Bioko Island Malaria Control Project (BIMCP) started in 2004 with the aim to reduce malaria transmission and to ultimately eliminate malaria.
Matias, Abrahan, Abaga Simon, Segura Luis, Slotman Michel A, Kleinschmidt, Immo, Reddy Michael R, Simon Abaga, Vamsi P Reddy, Reddy Vamsi P, Kulkarni, Vani, Abrahan Matias, Abaga, Simon, Kleinschmidt, I., Christopher Schwabe, Kulkarni, V., Overgaard Hans J, Slotman, Michel A, Reddy, V. P., Kleinschmidt Immo, Slotman, M. A., Overgaard, H. J., Reddy, M. R., Vani Kulkarni, Hans J Overgaard, Michael R Reddy, Matias Abrahan, Schwabe Christopher, Michel A Slotman, Schwabe, C., Reddy, Vamsi P, Kulkarni Vani, Immo Kleinschmidt, Luis Segura, Segura, L., Segura, Luis, Matias, A., Schwabe, Christopher, Abaga, S., Reddy, Michael R, Overgaard, Hans J   +39 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Vector and reservoir control for preventing leishmaniasis [PDF]

, 2015
CITATION: Gonzalez, U. et al. 2015. Vector and reservoir control for preventing leishmaniasis. Cochrane Database of Systematic Reviews, 8: Art. No.: CD008736, doi:10.1002/14651858.CD008736.pub2.The original publication is available at https://www ...
Enk, Claes, Tristan, Mario, Vélez Bernal, Iván Darío, Gonzalez, Urba, Alvar, Jorge, Esterhuizen, Tonya, Esterhuizen, Tonya M, Sinclair, David, Firooz, Alireza, Velez, Ivan D., Pinart, Mariona, Vélez, Ivan D   +11 more
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The Biological Control of the Malaria Vector [PDF]

Toxins, 2012
The call for malaria control, over the last century, marked a new epoch in the history of this disease. Many control strategies targeting either the Plasmodium parasite or the Anopheles vector were shown to be effective. Yet, the emergence of drug resistant parasites and insecticide resistant mosquito strains, along with numerous health, environmental,
openaire   +3 more sources