Results 81 to 90 of about 3,234,434 (300)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Loss-minimization control of vector-controlled induction motor drives [PDF]

[[abstract]]It is well known that the efficiency of induction motor drives under partial load can be improved via manipulation of its field. Among the numerous loss-minimization schemes proposed previously, the scheme that uses motor power factor as the ...
Yang, Sheng-ming
core   +1 more source

Molecular xenomonitoring of Wuchereria bancrofti infection in three different evaluation settings of lymphatic filariasis elimination programme in India

International Journal of Infectious Diseases
Objectives: Molecular xenomonitoring (MX) is a recommended post-validation surveillance tool for detecting early signs of lymphatic filariasis (LF) transmission.
Venkatesan Vasuki, Kaliannagounder Krishnamoorthy, Swaminathan Subramanian, Candasamy Sadanandane, Ramalingam Balasubramaniyan, Neelavathi Sivagnaname, Veerappan Padmanaban, Balakrishnan Vijayakumar, Vinayagam Sundarraj, Chokkalingam Palaniswamy, Prameela Baral, Purushothaman Jambulingam   +11 more
doaj   +1 more source

Evaluation of DawaPlus 3.0 and DawaPlus 4.0, deltamethrin–PBO combination nets against pyrethroid-resistant Anopheles culicifacies in experimental huts in India

Malaria Journal, 2020
Background The development of resistance in vectors is one of the major impediments for malaria control. Adding synergists to insecticides has proven to be an alternative choice for controlling resistant mosquitoes.
Kasinathan Gunasekaran, Sudhansu Sekhar Sahu, Tharmalingam Vijayakumar, Swaminathan Subramanian, Manju Rahi, Purushothaman Jambulingam   +5 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Chikungunya: an unusual vector-borne disease. Overview and new research trends [PDF]

, 2011
Since the huge epidemic of Chikungunya in 2006 in Réunion Island and in India, and since the small outbreak in 2007 in Italy, a few Chikungunya cases were reported in september 2010 in the south-east of France, indicating that even northern and developed
Dumont, Yves
core  

Sergentomyia (Neophlebotomus) chattiensis n. sp.: morphological and molecular description of a new sand fly species from Himachal Pradesh, India

Frontiers in Insect Science
IntroductionHimachal Pradesh, an ecologically diverse state in northern India, has recently emerged as a focus of atypical cutaneous leishmaniasis. As part of a molecular xenomonitoring, systematic entomological surveillance of sand flies resulted in the
Harish Kumar Shah, P. A. Fathima, Manju Rahi, Prasanta Saini   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Impact of climatic factors on the occurrence of malaria in hyper, high, moderate and low endemic States in India from 1995 to 2023

Malaria Journal
Background Malaria has been surging in India for the past 3 years after reaching the recorded low in 2021. Among the possible reasons for this unexpected surge of cases, such as insufficient surveillance, slow and aggregated data reporting, endemic ...
Muniaraj Mayilsamy, Rajagopal Parthasarathy, Rajamannar Veeramanoharan, Paramasivan Rajaiah   +3 more
doaj   +1 more source