Results 71 to 80 of about 3,337 (213)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Principles and Methods of Servomotor Control: Comparative Analysis and Applications

Applied Sciences
Servomotors have found widespread application in many areas, such as manufacturing, robotics, automation, and others. Thus, the control of servomotors is divided into various principles and methods, leading to a high diversity of control systems.
Siarhei Autsou, Karolina Kudelina, Toomas Vaimann, Anton Rassõlkin, Ants Kallaste   +4 more
doaj   +1 more source

An Investigation of Direct Torque Control and Hysteresis Current Vector Control for Motion Control Synchronous Reluctance Motor Applications

Power Electronics and Drives, 2019
Synchronous reluctance motor drives are one of the most attractive alternatives of permanent magnet synchronous motor drives and induction motor drives in the field of conventional industrial and household applications.
Vajsz Tibor, Számel László, Handler Árpád   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Switching Current Predictive Control of a Permanent Magnet Synchronous Motor Based on the Exponential Moving Average Algorithm

Energies
To improve the dynamic and steady-state control performance of permanent magnet synchronous motors under the three-vector model predictive current control method, this study proposes a switching current predictive control method based on the exponential ...
Fengming Yu, Jun Liu
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A Three-Vector Fast Model Predictive Control Method for Steady State Performance Improvement

IEEE Access
A fast three-vector model predictive control method based on an improved H8 inverter is proposed for the Permanent Magnet Synchronous Motor (PMSM) driven by a two-level three-phase voltage source inverter.
Yongzhen Zhang, Pu Cheng, Kai Shen, Weiming He, Di Nian, Jun Pan   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Discontinuous Current Vector Control Using PWM Method for Switched Reluctance Motor Driven With Asymmetric H-Bridge Converter

IEEE Open Journal of Industry Applications
This article proposes a discontinuous current vector control method for a three-phase switched reluctance motor driven by an asymmetric H-bridge converter.
Keitaro Kawarazaki, Ryoto Kojima, Nobukazu Hoshi   +2 more
doaj   +1 more source