Results 71 to 80 of about 17,974,907 (299)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Dual closed-loop vector PI control and deadbeat current control of permanent magnet synchronous motor

Sukkur IBA Journal of Emerging Technologies
Permanent magnet synchronous motors (PMSMs) offer advantages such as high torque, power density, and energy efficiency, making them essential in power electronics, aerospace, and daily life.
Syed Abid Ali Shah Bukhari, Vikram Kumar, Muhammad Ahsan Niazi, Qazi Sajid   +3 more
doaj   +1 more source

A Dual-Voltage-Vector Model-Free Predictive Current Controller for Synchronous Reluctance Motor Drive Systems

Energies, 2018
For current control in power conversion and motor drive systems, there exist three classic methods in the literature and they are the hysteresis current control (HCC), the sine pulse-width modulation (SPWM), and the space vector pulse width modulation ...
Cheng-Kai Lin, Jen-te Yu, Hao-Qun Huang, Jyun-Ting Wang, Hsing-Cheng Yu, Yen-Shin Lai   +5 more
doaj   +1 more source

Disease Prevention Through Vector Control: Guidelines for relief organisations [PDF]

, 1995
The number of refugees and displaced persons has increased greatly in recent years. At least 80 per cent of them are living in tropical or semi-tropical countries where vector borne diseases, such as malaria, dengue, kala azar, sleeping sickness ...
Thomson, Madeleine C
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Modulated Model-Free Predictive Control With Minimum Switching Losses for PMSM Drive System

IEEE Access, 2020
A modulated model-free predictive control with minimum switching losses (MSL-MMFPC) is proposed to improve the steady-state performance and reduce the switching losses for a permanent magnet synchronous motor (PMSM) drive system.
Yuchen Wang, Hongmei Li, Rundong Liu, Liguo Yang, Xianling Wang   +4 more
doaj   +1 more source

Clustering of vector control interventions has important consequences for their effectiveness : a modelling study [PDF]

, 2014
Vector control interventions have resulted in considerable reductions in malaria morbidity and mortality. When universal coverage cannot be achieved for financial or logistical reasons, the spatial arrangement of vector control is potentially important ...
Chitnis, Nakul, Melissa A Penny, Nakul Chitnis, Lutambi, Angelina Mageni, Angelina Mageni Lutambi, Briët, Olivier J. T., Smith, Thomas A., Olivier J T Briët, Thomas A Smith, Penny, Melissa A., Lutambi AM, Smith TA, Lutambi Angelina Mageni, Briët Olivier J. T., Penny Melissa A., Chitnis N, Chitnis Nakul, Briët OJ, Penny MA, Smith Thomas A.   +19 more
core   +2 more sources

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source