Results 71 to 80 of about 17,059,498 (307)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Comparing the Effectiveness of Malaria Vector-Control Interventions Through a Mathematical Model. [PDF]

, 2010
Although some malaria-control programs are beginning to combine insecticide-treated nets (ITNs) and indoor residual spraying (IRS), little is known about the effectiveness of such combinations.
Steketee, Richard, Chitnis, N., Schapira, A., Chitnis, Nakul, Steketee, R., Richard Steketee, Schapira, Allan, Nakul Chitnis, Allan Schapira, Smith, Thomas, Thomas Smith, Smith, T.   +11 more
core   +1 more source

Virtual Frequency Construction-Based Vector Current Control for Grid-Tied Inverter Under Imbalanced Voltage

IEEE Access, 2020
This paper proposes a fast phase capture (FPC) scheme and applies it to the control strategy of grid-tied inverters under imbalanced voltage. Firstly, a method for quickly extracting sequence components of power signals is derived through the symmetrical
Wu Binbing, Tian Yizhi, Chen Yuxi, Xiwang Abuduwayiti, Liansong Xiong   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

CURRENT VECTOR CONTROL OF PERMANENT-MAGNET SYNCHRONOUS MOTOR OF HYBRID VEHICLE ENGINE [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2009
Characteristics of traction permanent-magnet synchronous motor under current vector optimum control in the possible traction-speed mode area which are relevant for hybrid vehicle engine have been investigated.
S. Serikov
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Control Strategies for Open-End Winding Drives Operating in the Flux-Weakening Region [PDF]

, 2013
This paper presents and compares control strategies for three-phase open-end winding drives operating in the flux-weakening region. A six-leg inverter with a single dc-link is associated with the machine in order to use a single energy source.
KESTELYN, Xavier, SEMAIL, Eric, SANDULESCU, Paul, MEINGUET, Fabien, BRUYERE, Antoine   +4 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial targeted vector control is able to reduce malaria prevalence in the highlands of Burundi. [PDF]

, 2008
In a highland province of Burundi, indoor residual spraying and long-lasting insecticidal net distribution were targeted in the valley, aiming also to protect the population living on the hilltops.
Baza, D., Van Herp, M, Maes, P., Baza, D, Baza, Dismas, d' Alessandro, Umberto, Protopopoff, Natacha, Van Bortel, W., Maes, Peter, D'Alessandro, U., Protopopoff, N., Van Herp, Michel, Coosemans, Marc, D'Alessandro, Umberto, Van Herp, M., Coosemans, M, Maes, P, Coosemans, M., Van Bortel, W, D'Alessandro, U, Van Bortel, Wim, Marcotty, T, Marcotty, Tanguy, Marcotty, T., Protopopoff, N   +24 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source