Results 91 to 100 of about 600,320 (348)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Overcoming insecticide resistance in Anopheles mosquitoes by using faster-acting solid forms of deltamethrin

Malaria Journal, 2023
Background Controlling malaria-transmitting Anopheles mosquitoes with pyrethroid insecticides is becoming increasingly challenging because of widespread resistance amongst vector populations.
Jessica Carson, Bryan Erriah, Stephania Herodotou, Alexander G. Shtukenberg, Leilani Smith, Svetlana Ryazanskaya, Michael D. Ward, Bart Kahr, Rosemary Susan Lees   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Preparation and Use of a Yeast shRNA Delivery System for Gene Silencing in Mosquito Larvae

, 2018
The mosquito genome projects facilitated research in new facets of mosquito biology, including functional genetic studies in the dengue and Zika virus vector Aedes aegypti and the primary African malaria vector Anopheles gambiae.
Keshava Mysore, Realey, Jacob S., Molly Duman-Scheel, Jacob S. Realey, David W. Severson, Severson, David W., Na Wei, Mysore, Keshava, Scheel, Nicholas D., Wei, Na, Hapairai, Limb K., Duman-Scheel, Molly, Limb K. Hapairai, Nicholas D. Scheel   +13 more
core   +1 more source

Leishmania manipulation of sand fly feeding behavior results in enhanced transmission [PDF]

, 2007
In nature the prevalence of Leishmania infection in whole sand fly populations can be very low (
Rogers, Matthew E, Rogers Matthew E, Bates, Paul, Matthew E. Rogers, Matthew E Rogers, Bates, Paul A, Paul A Bates, Rogers, Matthew E., Bates Paul A, Paul A. Bates   +9 more
core   +1 more source

First report of N1575Y mutation in pyrethroid resistant Anopheles gambiae s.l. in Nigeria

Scientific African, 2020
In view of recent findings that codon 1575 mutation increases the L1014F-mediated resistance in Anopheles mosquitoes, we investigated the presence of this mutation in four States with intense pyrethroid resistance in Nigeria.
A. Tolulope Oyeniyi, A. Olufemi Adeogun, E. Taiwo Idowu, Bola Oboh, Abiodun Olakiigbe, Oluwakemi Adesalu, Tawakalitu Jimoh, T. Samson Awolola   +7 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Matrix-based vector representations in neural networks for classifying molecular biology data

Bioinformatics Advances
Abstract Summary Selecting an appropriate classifier is essential for achieving accurate classification. In this study, we propose novel neural network (NNs)-based alternatives to standard classifiers as support vector machines.
Loris Nanni, Sheryl Brahnam, Daniel Fusaro   +2 more
openaire   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Automating fault tolerance in high-performance computational biological jobs using multi-agent approaches [PDF]

, 2014
Background: Large-scale biological jobs on high-performance computing systems require manual intervention if one or more computing cores on which they execute fail.
Varghese, Blesson, McKee, Gerard, Alexandrov, Vassil   +2 more
core   +1 more source