Results 81 to 90 of about 600,320 (348)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Exploring SIMD for molecular dynamics, using Intel Xeon processors and Intel Xeon Phi coprocessors [PDF]

, 2013
We analyse gather-scatter performance bottlenecks in molecular dynamics codes and the challenges that they pose for obtaining benefits from SIMD execution. This analysis informs a number of novel code-level and algorithmic improvements to Sandia's miniMD
Jarvis, S. A.; id_orcid, Simon J. Pennycook, Smelyanskiy, M., S.A. Jarvis, Pennycook, Simon J., Chris J. Hughes, M. Smelyanskiy, Hughes, C. J., Hughes, Chris J., Jarvis, Stephen A.   +9 more
core   +1 more source

Malnutrition exacerbates pathogenesis of Lutzomyia longipalpis sand fly-transmitted Leishmania donovani

Communications Biology
Visceral leishmaniasis (VL) is transmitted by Leishmania-infected sand fly bites and malnutrition is a known risk factor in human VL. Models using sand fly transmission or malnutrition promote parasite dissemination.
Eva Iniguez, Johannes Doehl, Pedro Cecilio, Tiago Donatelli Serafim, Caroline Percopo, Yvonne Rangel-Gonzalez, Somaditya Dey, Elvia J. Osorio, Patrick Huffcutt, Sofia Roitman, Claudio Meneses, Mara Short, Jesus G. Valenzuela, Peter C. Melby, Shaden Kamhawi   +14 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Caracterização molecular de uma fosfotransferase (Arginina Quinase) de Trypanosoma rangeli [PDF]

, 2014
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.O Trypanosoma rangeli é um parasito hemoflagelado que infecta mamíferos silvestres e domésticos, assim como seres humanos.
Pontes, Carime Lessa Mansur
core  

The structural basis for the integrity of adenovirus Ad3 dodecahedron [PDF]

, 2012
During the viral life cycle adenoviruses produce excess capsid proteins. Human adenovirus serotype 3 (Ad3) synthesizes predominantly an excess of free pentons, the complexes of pentameric penton base and trimeric fiber proteins, which are responsible for
Fender, Pascal, Monika Zochowska (134637), Jean-Pierre Andrieu, Ewa Szolajska (134629), Stephen Cusack (134664), Burmeister, Wim P, Pascal Fender (132764), Szolajska, Ewa, Pascal Fender, Nerlo, Barbara, Burmeister, Wim P., Igor Andreev, Wim P. Burmeister (134634), Wim P Burmeister, Guy Schoehn, Jadwiga Chroboczek (134668), Andreev, Igor, Naskalska, Antonina, Stephen Cusack, Chroboczek, Jadwiga, Barbara Nerlo (134643), Ewa Szolajska, Chloe Zubieta (134662), Barbara Nerlo, Igor Andreev (134649), Andrieu, Jean-Pierre, Jadwiga Chroboczek, Chloe Zubieta, Monika Zochowska, Zochowska, Monika, Cusack, Stephen, Jean-Pierre Andrieu (134655), Schoehn, Guy, Antonina Naskalska, Guy Schoehn (27525), Zubieta, Chloe, Antonina Naskalska (134660)   +36 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Vector of Trypanosoma copemani identified as Ixodes sp.

, 2011
A total of 41 ticks were collected from 15 quokkas on Bald Island and 2 ticks from a Gilbert's potoroo from Two Peoples Bay. Three species of Ixodid ticks Ixodes australiensis, Ixodes hirsti and Ixodes myrmecobii were identified on the quokkas known to ...
Ditcham, W.G.F., Austen, J. M., Reid, S.A., Ditcham, W. G. F., Reid, S. A., Friend, J.A., Ryan, U. M., Austen, J.M., Friend, J. A., Ryan, U.M.   +9 more
core   +1 more source

Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria

Nature Communications
Most human pathogenic Leishmania species are zoonotic agents; therefore, sand fly-based control strategies are essential to prevent parasite circulation.
Pedro Cecilio, Luana A. Rogerio, Tiago D. Serafim, Kristina Tang, Laura Willen, Eva Iniguez, Claudio Meneses, Luis F. Chaves, Yue Zhang, Luiza dos Santos Felix, Wei Huang, Melina Garcia Guizzo, Pablo Castañeda-Casado, Marcelo Jacobs-Lorena, Jesus G. Valenzuela, Janneth Rodrigues, Fabiano Oliveira   +16 more
doaj   +1 more source

Progress on Chlorella in the area of molecular biology

, 2010
Unicellular green alga Chlorella is a kind of important eukaryotic microalga. A lot of work about Chlorella was reported in recent years with the rapid development of algal biotechnique.
O. Hagerup
semanticscholar   +1 more source