Results 61 to 70 of about 1,117,643 (337)

The complete mt genomes of Lutzia halifaxia, Lt. fuscanus and Culex pallidothorax (Diptera: Culicidae) and comparative analysis of 16 Culex and Lutzia mt genome sequences

Parasites & Vectors, 2019
Background Despite the medical importance of the genus Culex, the mitochondrial genome (mt genome) characteristics of Culex spp. are not well understood.
Ling Sun, Ting-Jing Li, Wen-Bo Fu, Zhen-Tian Yan, Feng-Ling Si, Yu-Juan Zhang, Qi-Meng Mao, Bruna Demari-Silva, Bin Chen   +8 more
doaj   +1 more source

Sufficient conditions for linear stability of complex-balanced equilibria in generalized mass-action systems [PDF]

arXiv, 2022
Generalized mass-action systems are power-law dynamical systems arising from chemical reaction networks. Essentially, every nonnegative ODE model used in chemistry and biology (for example, in ecology and epidemiology) and even in economics and engineering can be written in this form. Previous results have focused on existence and uniqueness of special
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development [PDF]

, 2014
Peer reviewedPublisher ...
Adams JC, Agathocleous M, Aihara K, Amy S. Findlay, Austin CP, Cayouette M, Cepko CL, Chizu Nakamoto, de Iongh R, Ehrlich D, Elaine Durward, Ewa D. Zakrzewska, Fekete DM, Flanagan JG, Frade JM, Galvez JM, Hansen MJ, Harada H, Harpavat S, Hashimoto T, Holt CE, Hu WY, Isenmann S, Jablonski MM, Jablonski MM, Jiang Y, Jiang Y, Katahira T, Koga A, Kuroda S, Layer PG, Marianne Bronner, Martinez-Morales JR, Masai I, Masaru Nakamoto, Matsuhashi S, Matsuhashi S, Matsuoka H, Matsuyama S, Matsuyama S, McCabe KL, McCabe KL, McLaughlin T, Moore SW, Munemasa Y, Nakamura R, Nelson BR, Nelson BR, Oyasu M, Patel A, Prada C, Price J, Rachel RA, Raymond SM, Sato Y, Snow RL, Soh-Leh Kuan, Stiemke MM, Strauss O, Takuma Endo, Wang JT, Watanabe TK, Wetts R, Xiang M, Yee JK, Zhang XM, Zhang XM, Zhufeng Ouyang   +67 more
core   +1 more source

Inferring interaction networks from transcriptomic data: methods and applications [PDF]

arXiv, 2023
Transcriptomic data is a treasure-trove in modern molecular biology, as it offers a comprehensive viewpoint into the intricate nuances of gene expression dynamics underlying biological systems. This genetic information must be utilised to infer biomolecular interaction networks that can provide insights into the complex regulatory mechanisms ...
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Empirical learning aided by weak domain knowledge in the form of feature importance [PDF]

, 2010
Standard hybrid learners that use domain knowledge require stronger knowledge that is hard and expensive to acquire. However, weaker domain knowledge can benefit from prior knowledge while being cost effective.
Iqbal, Ridwan Al
core   +1 more source

Stability of Boolean and continuous dynamics [PDF]

, 2011
Regulatory dynamics in biology is often described by continuous rate equations for continuously varying chemical concentrations. Binary discretization of state space and time leads to Boolean dynamics. In the latter, the dynamics has been called unstable if flip perturbations lead to damage spreading.
arxiv   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source