Results 21 to 30 of about 223,895 (260)
Optimality Conditions in Quasidifferentiable Vector Optimization [PDF]
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The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
VISUALIZATION SOFTWARE DEVELOPMENT FOR PROCEDURE OF MULTI-DIMENSIONAL OPTIMIZATION OF TECHNOLOGICAL PROCESS FUNCTIONAL PARAMETERS [PDF]
A method for multi-criteria optimization of the design parameters for technological object is described. The existing optimization methods are overviewed, and works in the field of basic research and applied problems are analyzed.
E. N. Ishakova, M. A. Tokareva
doaj
RATIONAL RECOVERY MODEL OF DEPOT PROCESSING EQUIPMENT AT THE INDUSTRIAL ENTERPRISE
Purpose. The problem of the maximum resources recovery of rolling stock repair depot of industrial enterprise with limited resources consumption, which are used in the system is today’s topical question.The main factors that affect the repair depot ...
M. I. Kapitsa, T. S. Hryshechkina
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
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Some cone separation results and applications
In this note we present some cone separation results in infinite dimensional spaces. Our approach is mainly based on two different types of cone outer approximation. Then we consider an application to vector optimization.
M. Durea
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INTERNATIONAL LOGISTICS SYSTEMS DESIGN AND EFFECTIVENESS EVALUATION
Purpose. In the paper the question of the development of a methodological approach to the determination of logistics systems’ performance and grounding of the most effective goods’ delivery schemes, based on the theory of functions and sets of multiple ...
N. V. Khalipova
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Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Vector‐valued optimal Lipschitz extensions [PDF]
AbstractConsider a bounded open set $\font\open=msbm10 at 10pt\def\R{\hbox{\open R}}U \subset \R^n$ and a Lipschitz function $\font\open=msbm10 at 10pt\def\R{\hbox{\open R}}g: \partial U \to \R^m$. Does this function always have a canonical optimal Lipschitz extension to all of U? We propose a notion of optimal Lipschitz extension and address existence
Sheffield, Scott Roger, Smart, Charles
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This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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