Results 51 to 60 of about 223,895 (260)

Super efficiency in vector optimization [PDF]

Transactions of the American Mathematical Society, 1993
We introduce a new concept of efficiency in vector optimization. This concept, super efficiency, is shown to have many desirable properties. In particular, we show that in reasonable settings the super efficient points of a set are norm-dense in the efficient frontier. We also provide a Chebyshev characterization of super efficient points for nonconvex
Borwein, J. M., Zhuang, D.
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Classification of corn kernels grades using image analysis and support vector machine

Advances in Mechanical Engineering, 2018
In order to classify the quality of corn kernels in an affordable, convenient, and accurate manner, a method based on image analysis and support vector machine is proposed.
Ang Wu, Juanhua Zhu, Yuli Yang, Xinping Liu, Xiushan Wang, Ling Wang, Hao Zhang, Jing Chen   +7 more
doaj   +1 more source

A fault diagnosis method of rolling bearing

Gong-kuang zidonghua, 2014
For parameter optimization of support vector machine in fault diagnosis method of rolling bearing based on support vector machine, an improved fruit fly optimization algorithm was proposed which took accuracy rate of pattern classification as taste ...
DONG Jianping, YANG Cheng, LU Xiaoli
doaj   +1 more source

Vector optimization

, 1996
We discuss three scalarizations of the multiobjective optimization from the point of view of the parametric optimization. We analize three important aspects: 1. What kind of singularities may appear in the different parametrizations, 2. Regularizations in the sense of Jongen, Jonker and Twilt, and in the sense of Kojima and Hirabayashi, 3.
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Wavelet Kernel Relevance Vector Machine Algorithm Based on Adaptive Kernel Parameter Optimization [PDF]

Jisuanji gongcheng, 2017
The traditional Relevance Vector Machine(RVM) algorithm is slow to train on large scale datasets,and the Gauss radial kernel cannot express the feature space completely.So based on adaptive kernel parameter optimization,this paper proposes a wavelet ...
GAO Mingzhe,XU Aiqiang,ZHANG Wei
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A

Molecular Therapy: Methods & Clinical Development, 2018
Potency is a key optimization parameter for hemophilia A gene therapy product candidates. Optimization strategies include promoter engineering to increase transcription, codon optimization of mRNA to improve translation, and amino-acid substitution to ...
Harrison C. Brown, Philip M. Zakas, Stephan N. George, Ernest T. Parker, H. Trent Spencer, Christopher B. Doering   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source