Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Numerical Analysis of Bypass Mass Injection on Thrust Vectoring of Supersonic Nozzle
MATEC Web of Conferences, 2018 High speed aerospace applications require rapid control of thrust (i.e. thrust vectoring) in order to achieve better manoeuvrability. Among the existing technologies, shock vector control is one of the efficient ways to achieve thrust vectoring.
Islam Md Shafiqul +2 more
doaj +1 more source
Multiaxis thrust vectoring using axisymmetric nozzles and postexit vanes on an F/A-18 configuration vehicle [PDF]
A ground-based investigation was conducted on an operational system of multiaxis thrust vectoring using postexit vanes around an axisymmetric nozzle.
Bowers, Albion H. +4 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Aeropropulsive characteristics of twin single-expansion-ramp vectoring nozzles installed with forward-swept wings and canards [PDF]
The Langley 16 foot transonic tunnel was used to determine the aeropropulsive characteristics of twin single-expansion-ramp vectoring nozzles installed in a wing-body configuration with forward-swept wings.
Capone, F. J., Mason, M. L.
core +1 more source
Tertiary flow injection thrust vectoring system Patent [PDF]
, 1965 Tertiary flow injection system for thrust vectoring of propulsive nozzle ...
Kepler, C. E.
core +1 more source
Intelligent Torque Vectoring Approach for Electric Vehicles with Per-Wheel Motors
Complex, 2018 Transport electrification is currently a priority for authorities, manufacturers, and research centers around the world. The development of electric vehicles and the improvement of their functionalities are key elements in this strategy.
Alberto Parra +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Research on Axisymmetric Vectoring Exhaust Nozzle Dynamic Characteristics Considering Aerodynamic and Thermal Loads Effect [PDF]
Journal of Applied Fluid MechanicsThe Axisymmetric Vectoring Exhaust Nozzle (AVEN) has been extensively studied in thrust vectoring technology due to its ability to achieve 360° vector deflection.
S. Yao +5 more
doaj +1 more source
Thrust vectoring for lateral-directional stability [PDF]
The advantages and disadvantages of using thrust vectoring for lateral-directional control and the effects of reducing the tail size of a single-engine aircraft were investigated.
Carpenter, Thomas, Peron, Lee R.
core +1 more source