Results 111 to 120 of about 1,757,511 (332)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Design of thrust vectoring exhaust nozzles for real-time applications using neural networks [PDF]
Thrust vectoring continues to be an important issue in military aircraft system designs. A recently developed concept of vectoring aircraft thrust makes use of flexible exhaust nozzles.
Markin, Robert E. +2 more
core +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Fluidics Thrust Vectoring Using Co-Flow Method
مجلة النهرين للعلوم الهندسية, 2017 Computational and experimental investigations of thrust vectoring using co flow method had been carried in the present work. The experimental investigation included design and construction of rig with rectangular duct with aspect ratio (4.4) in order to ...
Ali Abdul Almuhsen Al-Asady +1 more
doaj
Aerodynamics of thrust vectoring [PDF]
Thrust vectoring as a means to enhance maneuverability and aerodynamic performane of a tactical aircraft is discussed. This concept usually involves the installation of a multifunction nozzle.
Lan, C. Edward, Tseng, J. B.
core +1 more source
On the hardware reduction of z-datapath of vectoring CORDIC
, 2007 In this article we present a novel design of a hardware optimal vectoring CORDIC processor. We present a mathematical theory to show that using bipolar binary notation it is possible to eliminate all the arithmetic computations required along the z ...
Maharatna, Koushik +4 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
LANE CHANGE MANEUVER OF VIRTUAL HEAVY VEHICLE EQUIPPED WITH YAW MOMENT CONTROL
Perner’s Contacts, 2016 The goal of this article is to present a method for preparing a virtual heavy commercial vehicle for the analysis of the right-left torque vectoring technology effect.
Jan Fojtášek
doaj
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source