Results 131 to 140 of about 1,757,511 (332)
Conceptual design study report [PDF]
Conceptual design of Northrop V/STOL jet operations research supersonic ...
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Techniques utilized in the simulated altitude testing of a 2D-CD vectoring and reversing nozzle [PDF]
Simulated altitude testing of a two-dimensional, convergent-divergent, thrust vectoring and reversing exhaust nozzle was accomplished. An important objective of this test was to develop test hardware and techniques to properly operate a vectoring and ...
Block, H. Bruce +6 more
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Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Fluidic Jet Vectoring at Subsonic Flow ay Using Counter Flow Method
مجلة النهرين للعلوم الهندسية, 2017 Experimental & Computational and investigations of thrust vectoring by using counter flow method had been carried out in the present work. The experimental investigation included design and construction of test rig with rectangular duct with aspect ratio
Ali Abdul Almuhsen Al-Asady +1 more
doaj
Experimental performance of a ventral nozzle with pitch and yaw vectoring capability for SSTOVL aircraft [PDF]
Aircraft with supersonic, short takeoff, and vertical landing capability were proposed to replace some of the current high-performance aircraft. Several of these configurations use a ventral nozzle in the lower fuselage, aft of the center of gravity, for
Esker, Barbara S., Mcardle, Jack G.
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SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Jet vectoring using active switching
Journal of Fluid Science and TechnologySeveral studies have focused on jet vectoring and mixing enhancement using continuous jets for the secondary flow. In recent years, studies have applied synthetic jets to secondary flows, wherein the driving source can be easily downsized.
Koichi NISHIBE +3 more
doaj +1 more source
Powered-lift aircraft technology [PDF]
Powered lift aircraft have the ability to vary the magnitude and direction of the force produced by the propulsion system so as to control the overall lift and streamwise force components of the aircraft, with the objective of enabling the aircraft to ...
Deckert, W. H., Franklin, J. A.
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FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source