Results 41 to 50 of about 1,757,511 (332)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Model Predictive Control for Energy-Efficient Yaw-Stabilizing Torque Vectoring in Electric Vehicles With Four In-Wheel Motors

IEEE Access, 2023
This paper considers the problem of stabilizing and energy-efficient torque vectoring for electric vehicles with four independent in-wheel motors. In electric vehicles with four in-wheel motors, four electric motors are separately attached to the four ...
Sang Hyuk Kim, Kwang-Ki K. Kim
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Vector Groupoids

, 2010
The main purpose of this paper is to study the vector groupoids. This is an algebraic structure which combines the concepts of Brandt groupoid and vector space such that these are compatible.
Popuţa, Vasile, Ivan, Gheorghe
openaire   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

An energy-efficient torque-vectoring algorithm for electric vehicles with multiple motors

Mechanical systems and signal processing, 2019
In electric vehicles with multiple motors, the individual wheel torque control, i.e., the so-called torque-vectoring, significantly enhances the cornering response and active safety.
C. Chatzikomis, M. Zanchetta, P. Gruber, A. Sorniotti, B. Modic, T. Motaln, L. Blagotinsek, G. Gotovac   +7 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Primjena vektoriranog potiska s osvrtom na superupravljivost istraživackog zrakoplova X-31A

Promet (Zagreb), 2012
Vectored propulsion is a new concept of aircraft attitudecontrol by engines jet-deflection. Thrust vectoring researchhas become actualized during the last ten years, mainly formilitary application.The carried out experimental projects confirm the ...
Borivoj Galović, Sanja Steiner
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A Study of Torque Vectoring and Traction Control for an All-Wheel Drive Electric Vehicle

MATEC Web of Conferences, 2014
Common vehicle always experience energy loss during cornering manoeuver. Thus, to ensure it did not happened especially at high speed, a study of torque vectoring and traction control need to be made since it can increase the traction control of tyres ...
Maharun Mui’nuddin, Mohd Nor Mohamad Noor Iman   +1 more
doaj   +1 more source