Results 61 to 70 of about 1,757,511 (332)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Reinforcement Learning for Torque Vectoring in Electric Vehicles: A Review of Stability and Energy Optimization Methods

IEEE Open Journal of Vehicular Technology
Torque vectoring can enhance dynamic stability and concurrently enable efficient energy management in electric vehicles (EVs) through optimized torque distribution. Nevertheless, conventional torque vectoring schemes often rely on fixed models and tuning,
Reza Jafari, Shady S. Refaat, Amin Paykani, Pedram Asef, Pouria Sarhadi   +4 more
doaj   +1 more source

A torque vectoring optimal control strategy for combined vehicle dynamics performance enhancement and electric motor ageing minimisation* [PDF]

, 2016
In this paper we propose a control architecture that combines velocity, sideslip angle and yaw rate regulation with motor temperature regulation on a electric vehicle with four independent electric motors.
Kampanakis, Angelos, Longo, Stefano, Siampis, Efstathios, Velenis, Efstathios   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Evaluating Effectiveness of Implementing G.fast Technology in Ukraine’s Broadband Access Networks

Journal of Telecommunications and Information Technology
The article examines the feasibility of implementing the G.fast technology in the process of modernizing fixed broadband access networks operated in Ukraine.
Vitaliy Balashov, Vasyl Oreshkov, Iryna Barba, Dmytro Stelya, Ihor Makarov   +4 more
doaj   +1 more source

Comparison of Path Tracking and Torque-Vectoring Controllers for Autonomous Electric Vehicles

IEEE Transactions on Intelligent Vehicles, 2018
Steering control for path tracking in autonomous vehicles is well documented in the literature. Also, continuous direct yaw moment control, i.e., torque-vectoring, applied to human-driven electric vehicles with multiple motors is extensively researched ...
C. Chatzikomis, A. Sorniotti, P. Gruber, M. Zanchetta, Dan Willans, Bryn Balcombe   +5 more
semanticscholar   +1 more source

Thrust vectoring of an electric solar wind sail with a realistic sail shape [PDF]

, 2017
The shape of a rotating electric solar wind sail under the centrifugal force and solar wind dynamic pressure is modeled to address the sail attitude maintenance and thrust vectoring.
P. Toivanen, P. Janhunen
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source