Results 31 to 40 of about 106,049 (265)
Molecular Therapy: Methods & Clinical Development, 2018 Organotypic slice cultures recapitulate many features of an intact organ, including cellular architecture, microenvironment, and polarity, making them an ideal tool for the ex vivo study of viruses and viral vectors.
María C. Rosales Gerpe +8 more
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SEVA-Cpf1, a CRISPR-Cas12a vector for genome editing in cyanobacteria
Microbial Cell Factories, 2022 Background Cyanobacteria are photosynthetic autotrophs that have tremendous potential for fundamental research and industrial applications due to their high metabolic plasticity and ability to grow using CO2 and sunlight. CRISPR technology using Cas9 and
Sara Baldanta +2 more
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Molecular Therapy: Nucleic Acids, 2018 Viral vectors are rapidly being developed for a range of applications in research and gene therapy. Prototype foamy virus (PFV) vectors have been described for gene therapy, although their use has mainly been restricted to ex vivo stem cell modification.
John R. Counsell +18 more
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In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector
Cell Reports, 2015 Adeno-associated virus (AAV) vectors have emerged as a gene-delivery platform with demonstrated safety and efficacy in a handful of clinical trials for monogenic disorders.
Eric Zinn +11 more
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Parkinson’s Disease Detection by Processing Different ANN Architecture Using Vocal Dataset
Eurasian Journal of Science and Engineering, 2023 Parkinson’s Disease (PD) is a long-standing neurodegenerative condition of the central nervous system that mainly affects the motor system and origins full or partial damage in behavior, speech, motor reflexes, mental processing, and other energetic ...
Yusra Mohammed M. Salih +1 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Multifunctional SEVA shuttle vectors for actinomycetes and Gram‐negative bacteria
MicrobiologyOpen, 2020 Actinomycetales, such as the genus Streptomyces, are well‐known cell factories employed to produce a wide variety of secondary metabolites for industrial use.
Coral García‐Gutiérrez +6 more
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The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Named Entity Recognition Model Based on the Fusion of Word Vectors and Category Vectors
IEEE AccessNamed entity recognition (NER) in deep learning mode heavily relies on the processing and analysis of text vectors. This paper introduces an NER model based on deep learning techniques, emphasizing the fusion of word vectors and category vectors to ...
Yang Zhou +3 more
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source