Results 51 to 60 of about 726,516 (374)
Diabetes, Metabolic Syndrome and Obesity, 2020 Guangrui Chai,1 Shu Liu,2 Hongwei Yang,1 Guoqiang Du,3 Xiaolong Chen1 1Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China; 2Department of Geratology, The First Affiliated ...
Chai G, Liu S, Yang H, Du G, Chen X
doaj
H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]
, 2009 Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi +13 more
core +1 more source
Effect of Valeriana Sysimberifolia Extract on VEGF Expression in A549 Cell Line
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2020 BACKGROUND AND OBJECTIVE: Today, the use of medicinal plants in the treatment of cancer is more important due to its fewer side effects. Vascular endothelial growth factor (VEGF) is one of the most important factors in stimulating angiogenesis and ...
S Chegini, F Tafvizi, H Noorbazargan
doaj
Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway
International Journal of Molecular Sciences, 2018 Anti-angiogenic therapy is one of the promising strategies for many types of solid cancers. Bevacizumab (Avastin), a recombinant humanized monoclonal antibody of vascular endothelial growth factor (VEGF) A, was approved for the first time as an anti ...
Yoshiro Itatani +3 more
semanticscholar +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Effect of exercise on HIF-1 and VEGF signaling
Journal of Physical Fitness and Sports Medicine, 2012 This review summarizes the literature describing the significance of various conditions, such as hypoxia, oxidative stress, and, above all, physical exercise, in the hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF ...
Hideki Ohno +8 more
doaj +1 more source
Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback [PDF]
, 2005 In developing limb skin, peripheral nerves are required for arterial differentiation, and guide the pattern of arterial branching. In vitro experiments suggest that nerve-derived VEGF may be important for arteriogenesis, but its role in vivo remains ...
Anderson, David J. +4 more
core +1 more source
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors
Journal of Experimental Medicine, 2015 VEGF-A production in the tumor microenvironment enhances expression of PD-1 and other inhibitory checkpoints involved with CD8+ T cell exhaustion, which can be reversed with anti-VEGF/VEGFR treatment.
T. Voron +17 more
semanticscholar +1 more source