Results 41 to 50 of about 313,180 (251)

Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells [PDF]

Kosin Medical Journal, 2019
Objectives Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several ...
Cho Eui Jin, Jung Hyun Lee, Geun Joo Kim, Tae Hwa Lee   +3 more
doaj   +1 more source

Circulating miRNA 20a, miRNA 140-5p and VEGF as Predictive Biomarkers of Metastasis in Liquid Biopsy of Breast Cancer Patients

Archives of Pharmaceutical Sciences Ain Shams University, 2021
Background: MicroRNAs (miRNAs) are critical modulators in breast carcinogenesis. Metastasis remains the underlying cause of breast cancer related mortality.
Sherihan G AbdelHamid, Hany AbdelAziz, Amany Kamal   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Effects of Carvacrol in an Experimentally Induced Esophageal Burn Model: Expression of VEGF and Caspase-3 Proteins

Journal of Investigative Surgery, 2021
Introduction We investigated the therapeutic effects of carvacrol in an experimental esophageal burn rat model with immunohistochemical techniques. Materials and Methods: Three groups were included in this study, composed of eight Wistar albino rats each.
Hikmet Zeytun, Ebru Gökalp Özkorkmaz
doaj   +1 more source

???????????????????? ???????????????????? ?? ?????????????????????? ?????????????????????????????? ?????????????? ?????????? (VEGF) ?? ?????????????? ?????????????????? ?? ?????????????????????? ?????? [PDF]

, 2019
This paper presents the results of the study of serum levels of melatonin and VEGF with various severity of psoriasis and with sleep disorder and without it. The study revealed significant increase of VEGF levels and decrease of serum levels of melatonin with maximum deviation in severe disease.
openaire   +3 more sources

VEGF: inflammatory paradoxes [PDF]

Pathogens and Global Health, 2015
Invited commentary on ‘VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria’ and ‘Vascular Endothelial Growth factor (VEGF) and Lovastatin suppress the inflammatory response to Plasmodium berghei infection and protect against Experimental Cerebral Malaria’ by Canavese et al.
Georges E R, Grau, Mike B, Thompson, Christopher R, Murphy   +2 more
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The pore size of chitosan-Aloe vera scaffold and its effect on VEGF expressions and woven alveolar bone healing of tooth extraction of Cavia cobaya

Dental Journal, 2020
Background: Pore size of scaffolds affects cellular activity, stimulates angiogenetic factors of vascular endothelial growth factor (VEGF), synthesises new blood vessels to regulate migration and proliferation, and accelerates alveolar bone healing of ...
S. Sularsih
doaj   +1 more source

VEGF-A/VEGF-B/VEGF-C expressions in non-hereditary, non-metastatic phaeochromocytoma.

Histology and histopathology, 2021
Vascular endothelial growth factor (VEGF) is important in pathogenesis of different cancers. The aim of this study is to investigate the relationships between different VEGFs and clinicopathological factors in patients with phaeochromocytomas. Twenty patients (10 men; 10 women) with non-hereditary, non-metastatic phaeochromocytomas were examined for ...
Abe, Ichiro, Islam, Farhadul, Lo, Chung Yau, Liew, Victor, Pillai, Suja, Lam, Alfred K   +5 more
openaire   +3 more sources