Results 51 to 60 of about 413,657 (289)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Intraluminal application of vascular endothelial growth factor enhances healing of microvascular anastomosis in a rat model [PDF]
, 2005 Background: Early reconstitution after injury to the endothelium is an important feature for reducing a number of vessel wall pathologies. We investigated the effect of vascular endothelial growth factor ( VEGF) and its impact on the vascular remodeling ...
Hollenberg, S. M. +8 more
core +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Immunohistochemical Localization of VEGF and VEGF Receptors in Developing Human Tooth Germ [PDF]
, 2007 P(論文)Vascular endothelial growth factor (VEGF) is a major angiogenetic factor in both developmental and wound healing processes. Recent studies have shown the expression of VEGF mRNA in lung, kidney, heart, ovary and various organs.
中川, 敏浩 +17 more
core
Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells [PDF]
Kosin Medical Journal, 2019 Objectives Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several ...
Cho Eui Jin +3 more
doaj +1 more source
Archives of Pharmaceutical Sciences Ain Shams University, 2021 Background: MicroRNAs (miRNAs) are critical modulators in breast carcinogenesis. Metastasis remains the underlying cause of breast cancer related mortality.
Sherihan G AbdelHamid +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Journal of Investigative Surgery, 2021 Introduction We investigated the therapeutic effects of carvacrol in an experimental esophageal burn rat model with immunohistochemical techniques. Materials and Methods: Three groups were included in this study, composed of eight Wistar albino rats each.
Hikmet Zeytun, Ebru Gökalp Özkorkmaz
doaj +1 more source
Structural Basis of Lymphangiogenic Receptor VEGFR-3 Activation Mediated by Distinctive Clustering of the Ligand-Receptor Complex. [PDF]
Adv Sci (Weinh)VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Cho R +6 more
europepmc +2 more sources