Results 1 to 10 of about 3,320 (216)
VEGF Receptor Signaling in Tumor Angiogenesis [PDF]
The Oncologist, 2000 Abstract The growth of human tumors and development of metastases depend on the de novo formation of blood vessels. The formation of new blood vessels is tightly regulated by specific growth factors that target receptor tyrosine kinases (RTKs).
Gerald McMahon
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VEGF, its receptors and the Tie receptors in recurrent miscarriage [PDF]
Molecular Human Reproduction, 2000 The aetiology of recurrent miscarriage (at least three consecutive miscarriages) usually remains unsolved. The vascular endothelial growth factor (VEGF) family of proteins, together with their receptors and the Tie (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains) receptors, are crucial for embryonic development ...
Piia Vuorela +3 more
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The Role of VEGF and VEGF Receptors in Carcinogenesis [PDF]
Journal of Carcinogenesis & Mutagenesis, 2012 The vascular endothelial growth factor (VEGF) family and its associated cognate receptors are critical components of angiogenesis, the process of new blood vessel formation. Under normal conditions, angiogenesis supports organism development and tissue homeostasis in a tightly controlled fashion.
Kendall S. Frazier, Kevin French
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Aflibercept—a Decoy VEGF Receptor [PDF]
Current Oncology Reports, 2014 Aflibercept (known as ziv-aflibercept in the USA and sold under the trade name Zaltrap®) is a human recombinant fusion protein with antiangiogenic effects that functions as a decoy receptor to bind vascular endothelial growth factors A and B and placental growth factor.
Kristen K. Ciombor, Jordan Berlin
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Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
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Functional VEGF and VEGF receptors are expressed in human medulloblastomas [PDF]
Neuro-Oncology, 2007 Vascular endothelial growth factor (VEGF) is one of the key regulators of tumor neoangiogenesis. It acts through two types of high-affinity tyrosine kinase receptors (VEGF receptor-1 [VEGFR-1]/fms-related tyrosine kinase 1 [Flt-1] and VEGFR-2/kinase domain receptor [KDR]) expressed on endothelial cells.
SLONGO, MARA LILIANA +8 more
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Advanced Healthcare Materials, Volume 11, Issue 24, December 21, 2022., 2022 3D bioprinting enables the creation of 3D tumor‐like constructs in the laboratory by loading a mixture of cells and biomaterials. This review provides an overview of key considerations of the complex tumor microenvironment and matrix design when developing 3D tumor models.
MoonSun Jung +4 more
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VEGF receptor signaling in vertebrate development [PDF]
Organogenesis, 2008 The secreted glycoprotein vascular endothelial growth factor A (VEGF or VEGFA) affects many different cell types and modifies a wide spectrum of cellular behaviors in tissue culture models, including proliferation, migration, differentiation and survival.
Vieira, J., Ruhrberg, C., Schwarz, Q.
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Advanced Healthcare Materials, Volume 11, Issue 24, December 21, 2022., 2022 Practicing the art of manufacturing densely cellular solid organs on demand will require the production of billions of stem cells. Here, an optimized pipeline is presented for growing up to 4 billion human induced pluripotent stem cells in automated bioreactor systems.
Debbie L. L. Ho +21 more
wiley +1 more source
Advanced Healthcare Materials, Volume 12, Issue 1, January 2, 2023., 2023 A novel micro‐sol (MS)@carboxymethyl chitosan (CMC)‐collagen (Col) biphasic bionic periosteum is constructed and its feasibility in bone regeneration is tested in the study. The biphasic bionic periosteum can coordinate the conversion of macrophages (Mφ) subtypes through controlled release of interleukin‐4 (IL‐4) and realize the controllable conversion
Zonghan Xu +10 more
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