A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis. [PDF]
Nat Commun, 2017 Non-classical secretory vesicles, collectively referred to as extracellular vesicles (EVs), have been implicated in different aspects of cancer cell survival and metastasis.
Feng Q +8 more
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Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. [PDF]
Journal of Clinical Investigation, 1995 Endothelial cells constitute an essential integrator of factors that effect blood vessel remodeling induced by chronic hypoxia. We hypothesized that vascular endothelial growth factor (VEGF) may participate in the lung response to acute and to chronic ...
Rubin M. Tuder, B E Flook, N. F. Voelkel
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The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling. [PDF]
PLoS Computational Biology, 2009 Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific receptors on the endothelial cells lining blood vessels. The signaling cascade triggered eventually leads to the formation of new capillaries, a process called ...
Marianne O Stefanini +3 more
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Inhibition of VEGF receptors causes lung cell apoptosis and emphysema [PDF]
Journal of Clinical Investigation, 2000 Pulmonary emphysema, a significant global health problem, is characterized by a loss of alveolar structures. Because VEGF is a trophic factor required for the survival of endothelial cells and is abundantly expressed in the lung, we hypothesized that ...
Yasunori Kasahara +7 more
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PLoS ONE, 2013 Vascular endothelial growth factor (VEGF) is up-regulated during mesothelial to mesenchymal transition (MMT) and has been associated with peritoneal membrane dysfunction in peritoneal dialysis (PD) patients.
María Luisa Pérez-Lozano +9 more
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Zebrafish VEGF receptors: a guideline to nomenclature. [PDF]
PLoS Genetics, 2008 In placental mammals (eutherians), there exist three paralogous genes of the vascular endothelial growth factor (VEGF) receptor family, namely FLT1 (also named VEGFR1), KDR (also named FLK1 and VEGFR2), and FLT4 (also named VEGFR3).
Jeroen Bussmann +4 more
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Impact of ligand binding on VEGFR1, VEGFR2, and NRP1 localization in human endothelial cells. [PDF]
PLoS Computational BiologyThe vascular endothelial growth factor receptors (VEGFRs) bind to cognate ligands to facilitate signaling pathways critical for angiogenesis, the growth of new capillaries from existing vasculature. Intracellular trafficking regulates the availability of
Sarvenaz Sarabipour +6 more
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Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives [PDF]
Signal Transduction and Targeted TherapyVascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maintenance of ...
Chunsik Lee +5 more
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Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells [PDF]
Oncogene, 2000 Shinichi Kanno +8 more
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Comparative in silico Survey of Retinoic Acids as Putative Biomolecules Against VEGF Receptors: A Glycomics-based Approach [PDF]
Journal of Cell and Molecular Research, 2021 In this study, putative interactions between all of the retinoic acid (RA) ligands (all-trans (At), 9-cis (9c), and 13-cis (13c)), and VEGF receptors (VEGFR-1, -2 and -3) were investigated.
Ali Fallah +3 more
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