Results 1 to 10 of about 2,608,192 (371)

Human EP3I prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression

Biochemical and Biophysical Research Communications, 2008
A critical event in tumor development is the formation of new blood vessels to provide oxygen, nutrients and growth factors to the rapidly growing cancer cells. This process of angiogenesis is complex, however, it is well established that vascular endothelial growth factor (VEGF)-mediated signaling is an important early event.
John W. Regan, Davelene D. Israel, Hiromichi Fujino, Tomoko Taniguchi, Toshihiko Murayama   +4 more
openaire   +3 more sources

Gene expression for VEGF-A, VEGF-C, and their receptors in murine lymphocytes and macrophages [PDF]

Biochemistry (Moscow), 2007
Vascular endothelial growth factors VEGF-A and VEGF-C are the main angiogenic factors that control growth of new blood and lymphatic vessels in the organism, and they also possess several immunoregulatory activities. Expression of VEGF-A and VEGF-C mRNA as well as mRNA for VEGF receptors in lymphocytes and macrophages of naive mice was investigated ...
A. V. Krylov, E. P. Kisseleva, O. I. Stepanova, V. I. Lioudyno   +3 more
openaire   +2 more sources

Functions of the VEGF/VEGF Receptor System in the Vascular System

Seminars in Thrombosis and Hemostasis, 2000
The vascular endothelial growth factor (VEGF)/VEGF receptor system plays a central regulatory role in physiological and pathological angiogenesis. During embryogenesis, the VEGF/VEGF receptor system is critically involved in the formation of the vascular system by regulating both the growth and the survival of blood vessels.
openaire   +3 more sources

Chapter 13 VEGF Receptor Signal Transduction

2008
Signal transduction by vascular endothelial growth factors (VEGFs) through their cognate VEGF receptor tyrosine kinases follows the consensus scheme for receptor tyrosine kinases. Thus, binding of ligand induces receptor dimerization and activation of the tyrosine kinase through transphosphorylation between receptor molecules, leading to initiation of ...
Lena Claesson-Welsh, Xiujuan Li, Masabumi Shibuya   +2 more
openaire   +3 more sources

VEGF‐A, VEGF‐D, VEGF receptor‐1, VEGF receptor‐2, NF‐KB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits

The FASEB Journal, 2006
Plaque angiogenesis may be associated with the development of unstable and vulnerable plaques. Vascular endothelial growth factors (VEGFs) are potent angiogenic factors that can affect plaque neovascularization. Our objective was to determine the effect of diabetes on atherosclerosis and on the expression of angiogenesis-related genes in ...
Himadri Roy, Shalini Bhardwaj, Mohan Babu, Ilze Kokina, Sanna Uotila, Tiia Ahtialansaari, Teemu Laitinen, Juhana Hakumaki, Markku Laakso, Karl‐Heinz Herzig, Seppo Ylä‐Herttuala, Himadri Roy, Shalini Bhardwaj, Mohan Babu, Ilze Kokina, Sanna Uotila, Tiia Ahtialansaari, Teemu Laitinen, Juhana Hakumaki, Markku Laakso, Karl‐Heinz Herzig, Seppo Ylä‐Herttuala   +21 more
openaire   +3 more sources

VEGF Receptor Signaling and Endothelial Function

IUBMB Life, 2001
AbstractAngiogenesis, the formation of new blood vessels from preexisting ones, is a central process during normal development and during pathological repair. Vascular endothelial growth factor‐A (VEGF‐A) can stimulate both physiological and pathological angiogensis.
Johannes Waltenberger, Stefanie Kliche
openaire   +3 more sources

Gremlin: vexing VEGF receptor agonist [PDF]

Blood, 2010
Abstract Gremlins are mischievous creatures in English folklore, believed to be the cause of otherwise unexplainable breakdowns (the word gremlins is derived from the Old English “gremian” or “gremman,” “to vex”). Gremlin (or Gremlin-1) is also the designation of a secreted protein that is known to regulate bone formation during ...
openaire   +2 more sources

VEGF and VEGF Receptor Expression after Experimental Brain Contusion in Rat

Journal of Neurotrauma, 2005
Angiogenesis following traumatic brain injury (TBI) may be of importance not only for post-traumatic reparative processes but also for the development of secondary injuries. Vascular endothelial growth factor (VEGF) is a major regulator of endothelial cell proliferation, angiogenesis, and vascular permeability, though its possible involvement in ...
Christina von Gertten, Tiit Mathiesen, Ann-Christin Sandberg-Nordqvist, Mattias K. Sköld, Mattias K. Sköld, Staffan Holmin   +5 more
openaire   +3 more sources

VEGF and VEGF receptor levels in retinal and brain-derived endothelial cells

Biochemical and Biophysical Research Communications, 2002
Vascular endothelial cell growth factor (VEGF) is an endothelial cell-specific angiogenic and permeability-inducing factor that has been implicated in the pathogenesis of diabetic retinopathy. The objectives of this study are to compare VEGF and VEGF receptor expression between retinal and brain-derived endothelial cells cultured in 5 or 30 mM glucose ...
Paula Grammas, Talitha T. Rajah
openaire   +3 more sources

Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis.

Experimental Cell Research, 2006
M. Shibuya, L. Claesson-Welsh
semanticscholar   +1 more source