Results 291 to 300 of about 2,608,192 (371)

ASH2L‐K312‐Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, ASH2L‐K312‐lac is identified as a critical driver that promotes the malignant progression of hepatocellular carcinoma (HCC). Furthermore, through a comprehensive series of cell biological and molecular biological experiments, integrated with diverse animal models and systematic application of high‐throughput sequencing technologies, it ...
Hexu Han, Shuai Wang, Lixing Ma, Haimeng Yin, Xinxiang Cheng, YiFan Wang, Suqin Xia, Yi Zhang, Yue Zhang, Rong Zhu, Cuixia Liu, Dakun Zhao, Xiangqian Gu, He Zhu, Yin Yuan   +14 more
wiley   +1 more source

Polymorphisms in <i>VEGF</i> Signaling Pathway Genes and Their Potential Impact on Type 2 Diabetes Mellitus and Associated Complications: A Scoping Review. [PDF]

Biomedicines
Lima CMG, de Melo RC, Souza NMP, Silva PR, Aguiar DF, Ferreira LM, Volanski W, Picheth G, Rego FGM, Sari MHM.   +9 more
europepmc   +1 more source

Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines

, 2003
Sylvie Lantuéjoul, Bruno Constantin, Harry A. Drabkin, Christian Brambilla, Joëlle Roche, Élisabeth Brambilla   +5 more
openalex   +2 more sources

BACE2‐Induced Aberrant Lymphatic Network Aggravates the Local Inflammation in Arteriovenous Fistulas With Hyperphosphatemia

Advanced Science, EarlyView.
Vascular endothelial growth factor (VEGF)‐C secreted by Pi16+ fibro‐progenitors lays the foundation of lymphatic network in mouse arteriovenous fistulas (AVFs), whereas the elevated phosphate (Pi) in 5/6‐nephrectomy (Nx) mouse activates p‐ERK/p‐SP1/BACE2 pathway to generate additional soluble VEGFR‐3, which causes VEGF‐C unresponsiveness and defective ...
Kai Chen, Ziyin Guan, Hanwei Jin, Muladili Aihemaiti, Rong Mou, Mengting Yu, Yanhua Hu, Liujun Jiang, Xuliang Wang, Hao Yang, Ting Chen, Yao Lu, Hongkun Zhang, Qingbo Xu, Weidong Li   +14 more
wiley   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Efdamrofusp alfa: an insight into the novel drug and its use in age-related macular degeneration. [PDF]

Int J Retina Vitreous
Rath S, Ibrahim AA, Singh A, Das A, Sediqi SM, Khan NA, Panchal K, Mian SM.   +7 more
europepmc   +1 more source

Magnetized Cell‐Scaffold Constructs for Bone Tissue Engineering: Advances in Fabrication and Magnetic Stimulation

Advanced Science, EarlyView.
This review highlights the synthesis and applications of magnetized cells (MCs) and magnetized scaffolds (MSs) in advancing bone tissue engineering strategies. It further demonstrates how magnetic particles (MPs) improve scaffold properties and how external magnetic fields enhance mesenchymal stem cell adhesion, proliferation, and osteogenic ...
Elio Cinar SanSegundo, Mohammad J. Mirzaali, Lidy E. Fratila‐Apachitei, Amir A. Zadpoor   +3 more
wiley   +1 more source

Novel Insights Into Receptor Tyrosine Kinases in Pulmonary Arterial Hypertension. [PDF]

J Am Heart Assoc
Wu W, Kong F, Chen Z, Huang L, Nie X, Bian JS.   +5 more
europepmc   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source