Results 141 to 150 of about 14,079 (176)
VEGFR1 signaling in retinal angiogenesis and microinflammation
Progress in Retinal and Eye Research, 2021 Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A, -B, -C, -D, and placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 and 2 (VEGFR1/2), whereas VEGF-B and PlGF only bind VEGFR1. Although much research has been conducted on VEGFR2 to elucidate its key role in retinal diseases, recent efforts ...
Akiyoshi Uemura +2 more
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Biotechnology and Applied Biochemistry, 2014
AbstractBispecific antibody (BsAb) has been proved to be a very effective antitumor approach because of its distinctive advantages of immune‐mediated cytotoxicity. To enhance the ability to recruit and activate T lymphocytes for tumor‐specific killing, we constructed and prepared a recombinant human single‐chain Fv bispecific antibody (BsAb), named ...
Cheng Yi, Yu-Huan Kang, Lan-Tu Gou
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AbstractBispecific antibody (BsAb) has been proved to be a very effective antitumor approach because of its distinctive advantages of immune‐mediated cytotoxicity. To enhance the ability to recruit and activate T lymphocytes for tumor‐specific killing, we constructed and prepared a recombinant human single‐chain Fv bispecific antibody (BsAb), named ...
Cheng Yi, Yu-Huan Kang, Lan-Tu Gou
exaly +3 more sources
Pericytes Regulate Cerebral Perfusion through VEGFR1 in Ischemic Stroke
Cellular and Molecular Neurobiology, 2021Neurons in the penumbra (the area surrounding ischemic tissue that consists of still viable tissue but with reduced blood flow and oxygen transport) may be rescued following stroke if adequate perfusion is restored in time. It has been speculated that post-stroke angiogenesis in the penumbra can reduce damage caused by ischemia.
Qing-Wu Yang, Fangfei Li, Jun-Jie Yuan
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VEGF, VEGFR1, and VEGFR2 expression in melanoma
Journal of Clinical Oncology, 20078520 Background: Metastatic melanoma is a chemoresistant disease with poor prognosis. Angiogenesis plays a role in progression and metastasis of melanoma. Identifying angiogenic molecules that are differentially expressed between benign and malignant tissues may enable us to create an assay to predict sensitivity to antiangiogenic agents, thus ...
J. M. Mehnert +7 more
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Upregulation of VEGFR1 in a rat model of esophagogastric anastomotic healing
Acta Chirurgica Belgica, 2017Anastomotic leakage after gastrointestinal surgery is a significant cause of morbidity and mortality. Esophagogastric and colorectal anastomoses are vulnerable to leakage. Extended knowledge of growth factors and their receptors is needed to understand anatomic healing.The expression pattern of vascular growth factor receptor (VEGFR1-3), epidermal ...
Laura Christina Landes +7 more
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VEGFR1 as a Target for Cardiovascular Gene Therapy
Journal of Cardiovascular Translational ResearchVascular endothelial growth factor receptor 1 (VEGFR1) is a key regulator of endothelial function, angiogenesis, inflammation, and cardiomyocyte survival, with both beneficial and deleterious effects in cardiovascular disease. In this review, we provide some key information on the molecular biology governing VEGFR1 function, its role in cardiovascular ...
Yosef Eshetie Amare +2 more
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The soluble VEGFR1 concentration in the serum of patients with colorectal cancer
Surgery Today, 2014VEGFR is involved in complex biological processes, including inflammation and cancer development, progression and metastasis. Many proteins, including VEGFR, are proteolytically released from the surface of cells by a process known as ectodomain shedding.
Oranus, Abbasi +5 more
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Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential
Angiogenesis, 2014We studied whether plasma levels of angiogenic factors VEGF and placental growth factor (PlGF) in coronary artery disease patients or undergoing cardiac surgery are modified, and whether those factors modulate endothelial progenitor's angiogenic potential.A total of 143 patients' plasmas from two different studies were analyzed (30 coronary artery ...
D’audigier, Clément +19 more
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Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands
Science Signaling, 2009PlGF and VEGF-B exhibit dual effects on angiogenesis mediated by VEGF-A.
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VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae
Molecular and Cellular Biochemistry, 2017Altered placental angiogenesis is implicated in the pathophysiology of preeclampsia. We have earlier reported placental regional differences in oxidative stress markers and neurotrophins. Oxidative stress and neurotrophins are reported to regulate angiogenesis.
Akriti S, Sahay +6 more
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