Results 71 to 80 of about 14,079 (176)

Synthetic Antiangiogenic Vascular Endothelial Growth Factor—A Splice Variant Revascularizes Ischemic Muscle in Peripheral Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Alternative splicing in the eighth exon C‐terminus of VEGF‐A (vascular endothelial growth factor‐A) results in the formation of proangiogenic VEGF165a and antiangiogenic VEGF165b isoforms.
Adarshini Raja, Vijay Ganta
doaj   +1 more source

VEGF receptor expression decreases during lung development in congenital diaphragmatic hernia induced by nitrofen

Brazilian Journal of Medical and Biological Research, 2014
Changes in vascular endothelial growth factor (VEGF) in pulmonary vessels have been described in congenital diaphragmatic hernia (CDH) and may contribute to the development of pulmonary hypoplasia and hypertension; however, how the expression of VEGF ...
L. Sbragia, A.C.C. Nassr, F.L.L. Goncalves, A.F. Schmidt, C.C. Zuliani, P.V. Garcia, R.M. Gallindo, L.A.V. Pereira   +7 more
doaj   +1 more source

Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the Eye

PLoS ONE, 2011
VEGFR1 and 2 signaling have both been increasingly shown to mediate complications of ischemic retinopathies, including retinopathy of prematurity (ROP), age-related macular degeneration (AMD), and diabetic retinopathy (DR). This study evaluates the effects of blocking VEGFR1 and 2 on pathological angiogenesis and vascular leakage in ischemic ...
Hu Huang, Jikui Shen, Stanley A Vinores
openaire   +4 more sources

Mechanisms controlling the effects of bevacizumab (avastin) on the inhibition of early but not late formed corneal neovascularization.

PLoS ONE, 2014
PurposeTo evaluate the effects and underlying mechanisms of early and late subconjunctival injection of bevacizumab on the inhibition of corneal neovascularization (NV).MethodsCorneal NV was induced by closed eye contact lens wear followed by a silk ...
Wei-Li Chen, Yan-Ming Chen, Hsiao-Sang Chu, Chung-Tien Lin, Lu-Ping Chow, Chih-Ta Chen, Fung-Rong Hu   +6 more
doaj   +1 more source

Activation of the VEGFR1 Chromatin Domain [PDF]

Journal of Biological Chemistry, 2008
Debasree Dutta, Soma Ray, Jay L. Vivian, Soumen Paul   +3 more
openaire   +1 more source

Disrupting VEGF–VEGFR1 Interaction: De Novo Designed Linear Helical Peptides to Mimic the VEGF13-25 Fragment

Molecules, 2017
The interaction between vascular endothelial growth factor (VEGF) and its receptors (VEGFR) has important implications in angiogenesis and cancer, which moved us to search for peptide derivatives able to block this protein–protein interaction.
Beatriz Balsera, M. Ángeles Bonache, Marie Reille-Seroussi, Nathalie Gagey-Eilstein, Michel Vidal, Rosario González-Muñiz, María Jesús Pérez de Vega   +6 more
doaj   +1 more source

Combined Anti-PLGF and Anti-Endostatin Treatments Inhibit Ocular Hemangiomas

Cellular Physiology and Biochemistry, 2015
Background/Aims: The degree of neovascularization determines the aggressiveness of ocular hemangiomas (OH). So far, the anti-angiogenic treatments using either antagonists against vascular endothelial growth factor A (VEGF-A), or endostatin, do not ...
Hua Jiang, Xinyi Wu, Hong Wang, Chao Huang, Linna Zhang   +4 more
doaj   +1 more source

Impact of human leukocyte antigen-DPB1 rs9277535 and vascular endothelial growth factor receptor 1 rs9943922 on Rheumatoid arthritis susceptibility and activity in an Egyptian case-control study

Journal of the Arab Society for Medical Research
Background/aim Rheumatoid arthritis (RA) is one of the most common autoimmune systemic inflammatory diseases presenting with chronic articular and extra articular manifestations resulting in high incidences of deformities, disabilities, morbidities, and ...
Ingy Ashmawy, Mirhane Hassan, Abeer Ramadan, Maha Abdelhadi   +3 more
doaj   +1 more source

Inhibiting anti-angiogenic VEGF165b activates a miR-17-20a-Calcipressin-3 pathway that revascularizes ischemic muscle in peripheral artery disease

Communications Medicine
Background VEGF165a increases the expression of the microRNA-17-92 cluster, promoting developmental, retinal, and tumor angiogenesis. We have previously shown that VEGF165b, an alternatively spliced anti-angiogenic VEGF-A isoform, inhibits the VEGFR ...
Sonia Batan, Sivaraman Kuppuswamy, Madison Wood, Meghana Reddy, Brian Annex, Vijay Ganta   +5 more
doaj   +1 more source

The Association between Vascular Endothelial Growth Factor-related Factors with Severity of Multiple Sclerosis

Iranian Journal of Allergy, Asthma and Immunology, 2016
Previous studies have demonstrated that vascular endothelial growth factor (VEGF) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells.
Ebrahim Kouchaki, Bentolhoda Otroshi Shahreza, Saiedeh Faraji, Hassan Nikoueinejad, Mojtaba Sehat   +4 more
doaj