Results 91 to 100 of about 3,575,601 (344)

From Consumer Incomes to Car Ages: How the Distribution of Income Affects the Distribution of Vehicle Vintages [PDF]

open access: yes, 2008
This paper studies the relationship between consumer incomes and ages of the durable goods consumed. At the household level, it presents evidence from the Consumer Expenditure Survey of a negative correlation between incomes and ages of the vehicles ...
Yurko, Anna
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

MONITORING AND CONTROL OF VEHICLES FOR TRAFFIC SAFETY [PDF]

open access: yesAvtomobilʹnyj Transport (Harʹkov), 2013
Analyzed are reasons of commission of accidents as a variety of traffic rules violations. New ways to reduce, prevent and fix violations of traffic rules by equipment of vehicles system of monitoring and control are shown.
Mironov, K. O.
doaj  

How “International” Should a Third Conflicts Restatement Be in Tort and Contract? [PDF]

open access: yes, 2013
The main goal of this work is to gain knowledge of how and to what extent state-of-the-artsimulation tools can be used in a conceptual development phase for vehicle dynamics control atVolvo Car Corporation (VCC).The first part of the thesis deals with an
Gurov, Alexey, Sengupta, Abhinav
core   +1 more source

A Dynamic Boundary Guarding Problem with Translating Targets

open access: yes, 2009
We introduce a problem in which a service vehicle seeks to guard a deadline (boundary) from dynamically arriving mobile targets. The environment is a rectangle and the deadline is one of its edges.
Bopardikar, Shaunak D.   +2 more
core   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy