Results 41 to 50 of about 270,023 (312)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Moving from Walkability? Evaluation Traditional and Merging Data Sources for Evaluating Changes in Campus-Generated Greenhouse Gas Emissions [PDF]
, 2019 Universities are increasingly committing to reduce campus-generated greenhouse gas emissions, whether voluntarily or in response to a legal mandate. As an initial step to keeping these commitments, universities need an accounting of baseline greenhouse ...
Kawahara, Troy +4 more
core +1 more source
Gross polluters and vehicle emissions reduction
Nature Sustainability, 2022 Version to be published in Nature Sustainability.
Matteo Böhm +2 more
openaire +4 more sources
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
Vehicle emissions in a middle-sized city of China: Current status and future trends
Environment International, 2020 Vehicle emissions are regarded as an important contributor to urban air pollution in China and most previous studies focused on megacities. However, the vehicle pollution in middle-sized cities becomes more severe due to the increasing vehicle population
Shida Sun +10 more
doaj +1 more source
FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
High-resolution simulation of link-level vehicle emissions and concentrations for air pollutants in a traffic-populated eastern Asian city [PDF]
Atmospheric Chemistry and Physics, 2016 Vehicle emissions containing air pollutants created substantial environmental impacts on air quality for many traffic-populated cities in eastern Asia.
S. Zhang +10 more
doaj +1 more source
Can UK passenger vehicles be designed to meet 2020 emissions targets? A novel methodology to forecast fuel consumption with uncertainty analysis [PDF]
, 2015 Vehicle manufacturers are required to reduce their European sales-weighted emissions to 95 g CO2/km by 2020, with the aim of reducing on-road fleet fuel consumption. Nevertheless, current fuel consumption models are not suited for the European market and
core +2 more sources
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Cities, traffic, and CO2: A multidecadal assessment of trends, drivers, and scaling relationships [PDF]
, 2015 Emissions of CO2 from road vehicles were 1.57 billion metric tons in 2012, accounting for 28% of US fossil fuel CO2 emissions, but the spatial distributions of these emissions are highly uncertain.
Gately, Conor K. +2 more
core +1 more source