Results 41 to 50 of about 903,323 (287)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Tire Contact Force Equations for Vision-Based Vehicle Weight Identification

Applied Sciences, 2022
Overloaded vehicles have a variety of adverse effects; they not only damage pavements, bridges, and other infrastructure but also threaten the safety of human life.
Xuan Kong, Tengyi Wang, Jie Zhang, Lu Deng, Jiwei Zhong, Yuping Cui, Shudong Xia   +6 more
doaj   +1 more source

An investigation on vehicle overloading in Muar - Melaka road [PDF]

, 2013
Vehicle overloading is considered as one of the most substantial concerns in road transport due to a possible road surface damage. The ability of a pavement structure in carrying out its function reduces in line with the increase of traffic load ...
Marwan, Hazlina
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Development and Verification of Test Procedures for Detecting Overloading and Improper Loading in Commercial Vehicles Using a High-Speed Weigh-in-Motion System: A Case Study in Republic of Korea

Applied Sciences
Despite continued efforts by the Korean government to improve road safety, truck-related accidents remain disproportionately fatal, with a rate approximately 2.6 times higher than that of passenger vehicles.
Ji-Won Jin, Chan-Woong Choi
doaj   +1 more source

The Effect of Flexible Pavement Mechanics on the Accuracy of Axle Load Sensors in Vehicle Weigh-in-Motion Systems

Sensors, 2017
Weigh-in-Motion systems are tools to prevent road pavements from the adverse phenomena of vehicle overloading. However, the effectiveness of these systems can be significantly increased by improving weighing accuracy, which is now insufficient for direct
Piotr Burnos, Dawid Rys
doaj   +1 more source

Dynamics Simulation of Remotely Operated Vehicle-Fiber Optic Micro Cable System [PDF]

, 2008
Li Q, Xu H, Zhang Q, Wang X, Li ZG. Dynamics Simulation of Remotely Operated Vehicle-Fiber Optic Micro Cable System.
Li, ZhiGang, Li ZG(李智刚), Xu, Hongli, Zhang QF(张奇峰), Qiang Li, Li, Qiang ; https://orcid.org/, Wang, Xiaohui, Xiaohui Wang, Zhigang Li, Wang XH(王晓辉), Hongli Xu, Qifeng Zhang, Zhang, Qifeng, Li Q(李强), Xu HL(徐红丽)   +14 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Planning of Vehicle Routing with Backup Provisioning Using Wireless Sensor Technologies

Information, 2017
Wireless sensor technologies can be used by intelligent transportation systems to provide innovative services that lead to improvements in road safety and congestion, increasing end-user satisfaction.
Noélia Correia, Nuno Carvalho, Gabriela Schütz   +2 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source