Results 61 to 70 of about 903,323 (287)
Advanced Science, EarlyView.Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li +21 more
wiley +1 more source
Advanced Science, EarlyView.USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li +10 more
wiley +1 more source
Advanced Science, EarlyView.A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv +16 more
wiley +1 more source
Injuries associated with cycle rickshaws accidents
Journal of Emergencies, Trauma and Shock, 2014 Context: Cycle rickshaw is an important means of transportation in Urban India. Pedestrians, rickshaw users, rickshaw pullers, two wheeled vehicle users and cyclists are among the most vulnerable road user groups in terms of injuries and fatalities ...
Sanjay Meena +3 more
doaj +1 more source
Advanced Science, EarlyView.MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han +24 more
wiley +1 more source
Energies, 2019 A hybrid microgrid-powered charging station reduces transmission losses with better power flow control in the modern power system. However, the uncoordinated charging of battery electric vehicles (BEVs) with the hybrid microgrid results in ineffective ...
Dominic A. Savio +5 more
doaj +1 more source
Dynamic Reliability of Continuous Rigid-Frame Bridges under Stochastic Moving Vehicle Loads
Shock and Vibration, 2020 The current volume of freight traffic has increased significantly during the past decades, impacted by the fast development of the national transportation market.
Naiwei Lu +5 more
doaj +1 more source
Modelica Libraries for Linear Control Systems [PDF]
, 2009 This article presents and describes the new LinearSystems and Controller libraries which are developed to enhance analysis, design and simulation of linear control systems in Modelica.
Otter, Martin +5 more
core +1 more source
Advanced Science, EarlyView.Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang +11 more
wiley +1 more source
Exploring the co-benefits of truck payload management on profitability and CO2 emissions
npj Sustainable Mobility and TransportTruck overloading raises societal concerns by affecting transportation safety and environmental sustainability, yet the implications of truck payload management (TPM), such as maximum loading enforcement and empty-running optimization, remain ...
Hongyi Li +5 more
doaj +1 more source