Results 171 to 180 of about 2,789,801 (380)

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

A hybrid adaptive large neighborhood search for time-dependent open electric vehicle routing problem with hybrid energy replenishment strategies. [PDF]

PLoS One, 2023
Fan L.
europepmc   +1 more source

A savings based method for real-life vehicle routing problems [PDF]

, 2002
Anne Poot, G. Kant, Albert Wagelmans
openalex   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

A highway vehicle routing dataset during the 2019 Kincade Fire evacuation. [PDF]

Sci Data, 2022
Xu Y, Zhao X, Lovreglio R, Kuligowski E, Nilsson D, Cova TJ, Yan X.   +6 more
europepmc   +1 more source

A new hybrid genetic algorithm for the capacitated vehicle routing problem [PDF]

, 2003
James O. Berger, Mohamed Barkaoui
openalex   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Uncertain multilevel programming with application to omni-channel vehicle routing problem. [PDF]

J Ambient Intell Humaniz Comput, 2023
Gao R, Ma Y, Ralescu DA.
europepmc   +1 more source

Deferred item and vehicle routing within integrated networks [PDF]

, 2003
Karen Smilowitz, Alper Atamtürk, Carlos F. Daganzo   +2 more
openalex   +1 more source

Sustainable High‐Performance Aqueous Batteries Enabled by Optimizing Electrolyte Composition

Advanced Science, EarlyView.
Lithium‐free aqueous batteries provide a safe, low‐cost alternative to lithium‐ion batteries for energy storage. This study introduces an optimized electrolyte using inexpensive salts, enhancing both energy density and cycling stability. The resulting battery delivers high power and efficiency, demonstrating strong potential for supercapacitor ...
Raphael L. Streng, Samuel Reiser, Anatoliy Senyshyn, Sabrina Wager, Johannes Sterzinger, Peter Schneider, David Gryc, Mian Zahid Hussain, Aliaksandr S. Bandarenka   +8 more
wiley   +1 more source