Results 171 to 180 of about 2,789,801 (380)

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

open access: yesAdvanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui   +17 more
wiley   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

open access: yesAdvanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu   +13 more
wiley   +1 more source

A highway vehicle routing dataset during the 2019 Kincade Fire evacuation. [PDF]

open access: yesSci Data, 2022
Xu Y   +6 more
europepmc   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang   +9 more
wiley   +1 more source

Deferred item and vehicle routing within integrated networks [PDF]

open access: green, 2003
Karen Smilowitz   +2 more
openalex   +1 more source

Sustainable High‐Performance Aqueous Batteries Enabled by Optimizing Electrolyte Composition

open access: yesAdvanced Science, EarlyView.
Lithium‐free aqueous batteries provide a safe, low‐cost alternative to lithium‐ion batteries for energy storage. This study introduces an optimized electrolyte using inexpensive salts, enhancing both energy density and cycling stability. The resulting battery delivers high power and efficiency, demonstrating strong potential for supercapacitor ...
Raphael L. Streng   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy