Results 231 to 240 of about 1,013,695 (299)

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Understanding perceived ride safety and trust formation in robotaxi services under day and night conditions. [PDF]

Sci Rep
Liu Y, Li H, Pan Y.
europepmc   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Does road safety cointegrate with socio-economic conditions in rich developing countries? [PDF]

PLoS One
Alfaki IA, Grivna M, El Sadig M.
europepmc   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Driving safety evaluation of vehicles on curved bridges under frequent seismic excitations. [PDF]

Sci Rep
Wu T, He Z, Yin Z, Guo Z, Yao G, Wang B.
europepmc   +1 more source

Chemical Resistance of Modified Wood Veneers in Sustainable Load Bearing Elements

ACS Omega
Sebastian Wurm, Alexa Scheer, Georg Baumann, Markus Wagner, Kevin Vitzthum, Stefan Spirk, Florian Feist   +6 more
doaj   +1 more source

An efficient remote driving shift control method of unmanned heavy tracked vehicles based on manned data mining. [PDF]

Sci Rep
Jia W, Zhao Y, Zheng H, Hu P, Gao Y.
europepmc   +1 more source

The Highly Selective 5-HT_2B Receptor Antagonist MW073 Mitigates Aggressive Behavior in an Alzheimer's Disease Mouse Model. [PDF]

Cells
Acquarone E, Roy SM, Staniszewski A, Watterson DM, Arancio O.   +4 more
europepmc   +1 more source