Results 41 to 50 of about 871,280 (247)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Approach for machine learning based design of experiments for occupant simulation

Frontiers in Future Transportation, 2022
The complexity of crash scenarios in the context of vehicle safety is steadily increasing. This is especially the case on the way to mixed traffic challenges with non-automated and automated driving vehicles.
Bernd Schneider, Desiree Kofler, Gian Antonio D'Addetta, Heiko Freienstein, Maja Wolkenstein, Corina Klug   +5 more
doaj   +1 more source

Trust in Vehicle-to-Vehicle Communication [PDF]

, 2017
In traditional Pedestrian Automatic Emergency Braking (PAEB) system, vehicles equipped with onboard sensors such as radar, camera, and infrared detect pedestrians, alert the driver and/ or automatically take actions to prevent vehicle-pedestrian ...
Dankwa, Boakye, Raje, Rajeev R., Sanghavi, Darsh, Vijayan, Raghavendran   +3 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Commercial vehicles safety management

Third International Conference “Transport for Today’s Society “, 2021
Abstract – Monitoring and analysis of commercial vehicles safety is an important component of traffic safety management. In highly developed countries, despite the increase in the number ofvehicles on the road, the number of fatalities in traffic accidents is decreasing.
Mladenovic, Dusan, Stanisavljevic, Djordje, Ivkovic, Ivan, Sekulic, Dragan   +3 more
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cervical disc prostheses need a variable center of rotation for flexion / extension below disc level, plus a separate COR for lateral bending above disc level to more closely replicate in-vivo motion: MRI-based biomechanical in-vivo study

BMC Musculoskeletal Disorders, 2022
Background Cervical disc prostheses are used to preserve motion after discectomy, but they should also provide a near-physiological qualitative motion pattern. Nevertheless, they come in many completely different biomechanical concepts. This caused us to
Manfred K. Muhlbauer, Ernst Tomasch, Wolfgang Sinz, Siegfried Trattnig, Hermann Steffan   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Predicting the Tensile Properties of Automotive Steels at Intermediate Strain Rates via Interpretable Ensemble Machine Learning

World Electric Vehicle Journal
Evaluating the dynamic impact properties of automotive steels is critical for structural design and material selection, but physical testing methods result in high costs and long lead times.
Houchao Wang, Fengyao Lv, Zhenfei Zhan, Hailong Zhao, Jie Li, Kangte Yang   +5 more
doaj   +1 more source

Assessment of brain injury characterization and influence of modeling approaches

Scientific Reports, 2022
In this study, using computational biomechanics models, we investigated influence of the skull-brain interface modeling approach and the material property of cerebrum on the kinetic, kinematic and injury outputs.
Saichao Yang, Jisi Tang, Bingbing Nie, Qing Zhou   +3 more
doaj   +1 more source