Results 41 to 50 of about 1,013,695 (299)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Cervical disc prostheses need a variable center of rotation for flexion / extension below disc level, plus a separate COR for lateral bending above disc level to more closely replicate in-vivo motion: MRI-based biomechanical in-vivo study

BMC Musculoskeletal Disorders, 2022
Background Cervical disc prostheses are used to preserve motion after discectomy, but they should also provide a near-physiological qualitative motion pattern. Nevertheless, they come in many completely different biomechanical concepts. This caused us to
Manfred K. Muhlbauer, Ernst Tomasch, Wolfgang Sinz, Siegfried Trattnig, Hermann Steffan   +4 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Assessment of brain injury characterization and influence of modeling approaches

Scientific Reports, 2022
In this study, using computational biomechanics models, we investigated influence of the skull-brain interface modeling approach and the material property of cerebrum on the kinetic, kinematic and injury outputs.
Saichao Yang, Jisi Tang, Bingbing Nie, Qing Zhou   +3 more
doaj   +1 more source

Commercial vehicles safety management

Third International Conference “Transport for Today’s Society “, 2021
Abstract – Monitoring and analysis of commercial vehicles safety is an important component of traffic safety management. In highly developed countries, despite the increase in the number ofvehicles on the road, the number of fatalities in traffic accidents is decreasing.
Mladenovic, Dusan, Stanisavljevic, Djordje, Ivkovic, Ivan, Sekulic, Dragan   +3 more
openaire   +1 more source

Trust in Vehicle-to-Vehicle Communication [PDF]

, 2017
In traditional Pedestrian Automatic Emergency Braking (PAEB) system, vehicles equipped with onboard sensors such as radar, camera, and infrared detect pedestrians, alert the driver and/ or automatically take actions to prevent vehicle-pedestrian ...
Dankwa, Boakye, Raje, Rajeev R., Sanghavi, Darsh, Vijayan, Raghavendran   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Predicting the Tensile Properties of Automotive Steels at Intermediate Strain Rates via Interpretable Ensemble Machine Learning

World Electric Vehicle Journal
Evaluating the dynamic impact properties of automotive steels is critical for structural design and material selection, but physical testing methods result in high costs and long lead times.
Houchao Wang, Fengyao Lv, Zhenfei Zhan, Hailong Zhao, Jie Li, Kangte Yang   +5 more
doaj   +1 more source

A Dual-Channel End-to-End Speech Enhancement Method Using Complex Operations in the Time Domain

Applied Sciences, 2023
This study investigates the utilization of complex operations to perform multichannel speech enhancement in the time domain using a neural network. Previous studies have demonstrated the advantages of incorporating complex operations when designing ...
Jian Pang, Hongcheng Li, Tao Jiang, Hui Wang, Xiangning Liao, Le Luo, Hongqing Liu   +6 more
doaj   +1 more source