Results 121 to 130 of about 119,349 (309)

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

An Analysis of Vehicle-to-Grid in Sweden Using MATLAB/Simulink

With more electric vehicles introduced in society, there is a need for the further implementation of charging infrastructure. Innovation in electromobility may result in new charging and discharging strategies, including concepts such as smart charging ...
Leijon, Jennifer, Hjalmarsson, Johannes, Cecilia Boström, Boström, Cecilia, Jennifer Leijon, Daniel Brandell, Jéssica Santos Döhler, Santos Döhler, Jéssica,, Castellucci, Valeria,, Leijon, Jennifer,, Brandell, Daniel,, Boström, Cecilia,, Johannes Hjalmarsson, Santos Döhler, Jéssica, Brandell, Daniel, Castellucci, Valeria, Hjalmarsson, Johannes,, Valeria Castellucci   +17 more
core   +1 more source

Heuristic Greedy Scheduling of Electric Vehicles in Vehicle-to-Grid Microgrid Owned Aggregators. [PDF]

Sensors (Basel), 2022
Abdel-Hakim AE, Abo-Elyousr FK.
europepmc   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

A simulation study of the use of electric vehicles as storage on the New Zealand electricity grid

, 2012
This paper describes a simulation to establish the extent to which reliance on non-dispatchable energy sources, most typically wind generation, could in the future be extended beyond received norms, by utilizing the distributed battery capacity of an ...
Rogers, Bill, Apperley, Mark, Monigatti, Paul   +2 more
core  

Optimizing fairness in bi-directional charging for electric vehicles: A two-stage model for energy scheduling management

Next Energy
Electric vehicles (EVs) are rapidly replacing internal combustion cars in urban transportation markets. Smart charging technology and vehicle-to-grid systems enable bi-directional charging, allowing for load shifting and shaping, which reduces both ...
Xian-Long Lee, Mozhdeh Hematiboroujeni, Adel N. Toosi, Peter Pudney, Markus Wagner   +4 more
doaj   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Optimisation algorithms for the charge dispatch of plug-in vehicles based on variable tariffs [PDF]

Plug-in vehicles powered by renewable energies are a viable way to reduce local and total emissions and could also support a highly efficient grid operation.
Richter, Julius, Büttner, Markus, Dallinger, David, Link, Jochen   +3 more
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source