Results 201 to 210 of about 439,736 (262)

Dolutegravir developmental toxicity is mitigated by magnesium and folate in zebrafish embryos. [PDF]

Dis Model Mech
Cabrera RM, Mohamed A, Minowa R, Neugebauer KA, Gorelick DA.   +4 more
europepmc   +1 more source

Functional Fibers in Soft Robotics: Advances in Material, Structural, and Systemic Tactics

Advanced Robotics Research, EarlyView.
Fiber‐form robotic systems offer a scalable pathway toward embodied intelligence in soft robotics. This review surveys functional fibers as material, structural, and systemic elements, highlighting advances in responsive materials, architectural programing, and fabrication strategies.
Joonhee Won, Jaehyun Jang, Hyeonseo Kim, Inyoung Choi, Steve Park, Seongjun Park   +5 more
wiley   +1 more source

C92, a proton channel-blocking allosteric STING agonist generates robust antitumor activity. [PDF]

J Immunother Cancer
Banerjee M, Middya SK, Shrivastava R, Middya A, Pryde DC, Chakraborty D, Soram T, Mane N, Rawat N, Gautam A, Puniya K, Sharma P, Yadav DB, Sônego F, Thiam K, Mills JE, Mani S, Ghosh R, Basu S, Surya A.   +19 more
europepmc   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

PARP1 rewires neuroinflammatory and redox metabolism associated with reactive neuroglia in neuropathic pain. [PDF]

Redox Biol
Denaro S, D'Aprile S, Gervasi A, Russo V, Bellia F, Giallongo S, Lavoro A, Candido S, Braga A, Gourine AV, Li Volti G, Pasquinucci L, Amorini AM, Parenti C, Parenti R, Vicario N.   +15 more
europepmc   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

The effect of canagliflozin on hippocampal dendrite morphology in a model of Alzheimer's disease induced by intracerebroventricular injection of streptozotocin. [PDF]

Brain Struct Funct
Yazi S, Ozen B, Buldu B, Yalcin E, Karakose O, Cakmak O, Somunkiran S, Yananli HR, Sehirli US, Kirazli O.   +9 more
europepmc   +1 more source

Bounding the costs of electric vehicle managed charging-supply curves for scenarios from 2025 to 2050. [PDF]

Sci Data
Matsuda-Dunn R, Hale E, Estreich E, Lavin L, Konar-Steenberg G.   +4 more
europepmc   +1 more source

Human pancreatic ductal cells from non-diabetic donors function as non-professional antigen-presenting cells upon inflammatory cytokine exposure. [PDF]

Diabetologia
Erdem N, Arribas-Layton D, Zook HN, O'Meally D, Mares J, Quijano JC, Donohue C, Ortiz JA, Jou K, Vasavada RC, Montero E, Kaddis JS, Reijonen H, Ku HT.   +13 more
europepmc   +1 more source

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Factors Affecting Common Vehicle-to-Vehicle Collision Types

Transportation Research Record: Journal of the Transportation Research Board, 2006
The number of older drivers (65+ years old) is increasing as a result of the baby boom generation reaching retirement age and an increase in driver's license holders among the elderly. The types of collisions incurred by older drivers are compared with those of drivers 30 to 60 years old in vehicle-to-vehicle collisions using the General Estimates ...
Gudmundur F. Ulfarsson, Sungyop Kim, Eric T. Lentz   +2 more
openaire   +1 more source