Results 61 to 70 of about 437,592 (262)
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Research on Curve through Safety of Straddle-type Monorail Vehicle
机车电传动, 2016 Through the force analysis on straddle-type monorail vehicle bogie and the track beam, the safety performance evaluationindexes of straddle-type monorail vehicle through curve were studied, combined with railway and vehicle safety performance ...
DU Zixue +3 more
doaj
TYPES OF UNMANNED AERIAL VEHICLES
, 2023 The development of network technologies in recent years is now increasing interest in multi-purpose unmanned aerial vehicles yani drone per day. Let us give a brief overview of the application of drones in various fields.
openaire +2 more sources
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
Bogie of Hanged-type Monorail Vehicle
机车电传动, 2015 Bogie characteristic of a hanged-type monorail vehicle bogie was discussed. The key components of bogie such as frame, driving unit, traction hanging device, walking wheel and guide wheel, and the connection between vehicle and bogie were introduced ...
PU Quanwei +3 more
doaj
International Journal of Automotive Science and Technology, 2019 The choice of battery type for electric vehicles is of great importance. For electric vehicle manufacturers, this issue is the biggest engineering problem.
Nusret Tan, Yunus Emre Eki̇ci̇
doaj +1 more source
Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan +7 more
wiley +1 more source
Modelling behavioural interactions of drivers' in mixed traffic conditions
Journal of Traffic and Transportation Engineering (English ed. Online), 2018 Mixed traffic conditions are often prevalent in developing economies such as India, China, Bangladesh, etc. and are characterised by the presence of multiple vehicle types.
Caleb Ronald Munigety
doaj +1 more source
Advanced Engineering Materials, EarlyView.This article presents the design, modeling, and characterization of air‐pressure–actuated programmable vibroacoustic metamaterials (PVAMM). The study focuses on leveraging air pressure to dynamically tune resonance frequencies for effective noise attenuation.
William Kaal +2 more
wiley +1 more source