Results 61 to 70 of about 23,681,723 (385)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Vehicle Use Forecasting Model Based on Revealed and Stated Vehicle Type Choice and Utilisation Data [PDF]
, 1997 This research describes a new model of household vehicle use behavior by type of vehicle. Forecasts of future vehicle emissions, including potential gains that might be attributed to introductions of alternative-fuel (clean-fuel) vehicles, critically ...
Brownstone, David +2 more
core +3 more sources
Active driveline and suspension control to improve vehicle handling [PDF]
, 2006 This research focuses on the integration of roll moment distribution control and variable torque distribution control to improve vehicle handling and dynamics.
Cooper, Nicholas James
core +5 more sources
PLoS ONE, 2019 Vehicles can be classified by configuration as either bonnet-type or cab-over type according to engine location. Compared to bonnet-type, the front compartment of cab-over type vehicles is considerably shorter; thus, it may be less likely to absorb the ...
Fumihito Ito +4 more
doaj +1 more source
ANALISIS KECELAKAAN LALU LINTAS DI KOTA SEMARANG MENGGUNAKAN MODEL LOG LINIER
Media Statistika, 2016 Traffic accident is an event in the unanticipated and unintended involve vehicles with or without other road users, resulting in losses and/or loss of property. According Polrestabes Semarang number of traffic accidents decreased in 2014 compared to 2013,
Yuciana Wilandari +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A Based-Bottleneck Multiple Vehicle Type Dynamic Marginal Cost Model and Algorithm
Promet (Zagreb), 2012 Single vehicle type dynamic marginal cost model is extended to multiple vehicle type dynamic one based on time-dependent multiple vehicle type queue analysis at a bottleneck. A dynamic link model is presented to model interactions between cars and trucks,
Shuguang Li
doaj +1 more source
Prominent Injury Types in Vehicle Underbody Blast [PDF]
Military Medicine, 2019 Abstract Background To fully understand the injury mechanisms during an underbody blast (UBB) event with military vehicles and develop new testing standards specific to military vehicles, one must understand the injuries sustained by the occupants ...
Kathryn L, Loftis +3 more
openaire +2 more sources
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source