Results 101 to 110 of about 155,535 (377)

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Simulation of Vehicular Ad-hoc Network Routing Protocols with a Performance Analysis

Journal of Communications Software and Systems, 2015
Vehicular Ad-hoc Network (VANET), a subset of Mobile Ad-hoc networks (MANETs), is one of the emerging technologies of Road Transportation system. In recent years, the aspect of Vehicular Ad-hoc Network (VANET) is becoming an interesting research area as ...
Thangakumar Jeyaprakash, Rajeswari Mukesh   +1 more
doaj  

Security Challenges, Authentication, Application and Trust Models for Vehicular Ad Hoc Network- A Survey

, 2017
Vehicular Ad hoc Network could manage the various critical issues of road transport. That is why it is the most crucial field of research for most of the researchers.
Akash Vaibhav, Dilendra Shukla, Sanjoy Das, S. Sahana, P. Johri   +4 more
semanticscholar   +1 more source

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures

Advanced Science, EarlyView.
This study developed a 3D brain vascular niche model that capture the key features of glioblastoma including perivascular infiltration, gene signature, dormancy and chemo resistance, by comparing 3D model with in vivo condition using identical glioma stem cells.
Vivian K. Lee, Rut Tejero, Nathaniel Silvia, Anirudh Sattiraju, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Roland H. Friedel, Hongyan Zou, Guohao Dai   +10 more
wiley   +1 more source

Qualitative Based Comparison of Routing Protocols for VANET [PDF]

, 2011
Vehicular ad hoc network is one of the most promising applications of MANET that an inter communication system. In VANET nodes which are vehicles can move safety with high speed and generally must communicate quickly reliably.
Kumar, Jogendra, Kumar, Suresh, Narayan, K.D.   +2 more
core   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Mobility models for Vehicular Ad-hoc Network simulation [PDF]

2011 IEEE Symposium on Computers & Informatics, 2010
5 pages, 12 figures, International Journal of Computer ...
Vaishali D. Khairnar, S. N. Pradhan
openaire   +4 more sources

Trust management in vehicular ad hoc network: a systematic review

EURASIP Journal on Wireless Communications and Networking, 2015
The basis of vehicular ad hoc networks (VANETs) is the exchange of data between entities, and making a decision on received data/event is usually based on information provided by other entities. Many researchers utilize the concept of trust to assess the
Seyed Ahmad Soleymani, A. Abdullah, W. H. Hassan, M. Anisi, Shidrokh Goudarzi, Mir Ali Rezazadeh Baee, Satria Mandala   +6 more
semanticscholar   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source