Results 101 to 110 of about 44,882 (282)
Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy +16 more
wiley +1 more source
Development and status of vehicular ad hoc networks
Tongxin xuebao, 2007 Historical development,characteristics and application fields of vehicular ad hoc networks（VANET） were in-troduced briefly.The advantages and disadvantages were discussed with analysis and comparison if various classes of MAC and routing protocol were ...
CHANG Cu-yu, XIANG Yong, SHI Mei-lin
doaj +2 more sources
A collaborative routing protocol for video streaming with fog computing in vehicular ad hoc networks
International Journal of Distributed Sensor Networks, 2019 Vehicular ad hoc networks play an important role in the efficiency of road traffic by improving safety and acting as a facilitator of services for passengers, drivers, and public safety officers.
Paulo Bezerra +5 more
doaj +1 more source
Advanced Science, EarlyView.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang +9 more
wiley +1 more source
Advanced Science, EarlyView.This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou +7 more
wiley +1 more source
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Advanced Science, EarlyView.Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song +12 more
wiley +1 more source
On-demand Misbehavior Detection for Vehicular Ad Hoc Network
International Journal of Distributed Sensor Networks, 2016 Maintaining communication links of an established communication path that extends between source and destination nodes is a significant challenge in Vehicular Ad Hoc Networks due to movement of the vehicles. Operations of Vehicular Ad Hoc Network rely on
Yao-Hua Ho, Chun-Han Lin, Ling-Jyh Chen
doaj +1 more source
Environment-Aware Adaptive Reinforcement Learning-Based Routing for Vehicular Ad Hoc Networks. [PDF]
Sensors (Basel), 2023 Jiang Y, Zhu J, Yang K.
europepmc +1 more source