Results 51 to 60 of about 2,792 (256)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Latency Estimation-Based Data Delivery Scheme for Vehicular Ad Hoc Networks

International Journal of Distributed Sensor Networks, 2012
Data delivery is the most compelling issue for the applications in vehicular ad hoc networks. The characteristics of VAENTs such as highly dynamic topology and the road-constrained mobility pose great challenges for data delivery in vehicular ad hoc ...
Haigang Gong, Lingfei Yu, Ke Liu, Fulong Xu, Xiaomin Wang   +4 more
doaj   +1 more source

Transmission Capacity Analysis for Vehicular Ad Hoc Networks

IEEE Access, 2018
Traditional studies focused on the transmission capacity of vehicular ad hoc network (VANET) contains two deficiencies: the lack of a realistic model mimicking the behaviors of vehicles and the failure to consider the impacts from enhanced distributed ...
Xinxin He, Weisen Shi, Tao Luo
doaj   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

PASS: Parking-Lot-Assisted Carpool over Vehicular Ad Hoc Networks

International Journal of Distributed Sensor Networks, 2013
Information interaction is a crucial part of modern transportation activities. In this paper, we propose the idea of PASS: a parking-lot-assisted carpool method over vehicular ad hoc networks (VANETs). PASS aims at optimizing transport utilization by the
Jinqi Zhu, Yong Feng, Bang Liu
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

A survey on Battlefield Management Systems: Architecture, challenges, and future research directions

Alexandria Engineering Journal
Battlefield Management Systems (BMS) serve as critical software platforms that integrate communication and control. This survey provides a comprehensive overview of Battlefield Management Systems (BMS) and their integration with the Internet of ...
Sumayah A. Almuntasheri, Thuraya N.I. Alrumaih, Ibtihal A.L. Alablani, Bander A. Jabr, Mohammed J.F. Alenazi   +4 more
doaj   +1 more source

Self-Organized Clustering Architecture for Vehicular Ad Hoc Networks

International Journal of Distributed Sensor Networks, 2015
Vehicular Ad Hoc NETworks (VANETs) are likely to be deployed in the near future. Then, they will become the platform for much of the relayed information in the Internet of Things.
Cándido Caballero-Gil, Pino Caballero-Gil, Jezabel Molina-Gil   +2 more
doaj   +1 more source