Results 71 to 80 of about 2,792 (256)

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

A Survey on the Application of Evolutionary Algorithms for Mobile Multihop Ad Hoc Network Optimization Problems

International Journal of Distributed Sensor Networks, 2016
Evolutionary algorithms are metaheuristic algorithms that provide quasioptimal solutions in a reasonable time. They have been applied to many optimization problems in a high number of scientific areas. In this survey paper, we focus on the application of
D. G. Reina, P. Ruiz, R. Ciobanu, S. L. Toral, B. Dorronsoro, C. Dobre   +5 more
doaj   +1 more source

Improved Dual-Protected Ring Signature for Security and Privacy of Vehicular Communications in Vehicular Ad-Hoc Networks

IEEE Access, 2018
As illegal access control, privacy disclosure and other threats in vehicular ad-hoc networks become more prevalent, and the importance of safety and privacy protection in vehicular communications grows significantly.
Yi Han, Nuo-Nuo Xue, Bi-Yao Wang, Qi Zhang, Chun-Lei Liu, Wei-Shan Zhang   +5 more
doaj   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

A new application-layer overlay platform for better connected vehicles

International Journal of Distributed Sensor Networks, 2017
To support smart and converged services for autonomous vehicles, reliable vehicular ad hoc networks play important roles. To achieve this goal, this article proposes an application-layer overlay platform for hyper-connected vehicular ad hoc networks.
Jaemin Jang, Taemin Ahn, Junghee Han
doaj   +1 more source

Human‐Guided Bayesian Optimization Enables High‐Throughput Laser Annealing of Mesoporous SiOx Anodes for Lithium‐Ion Batteries

Advanced Science, EarlyView.
An empirical‐aided active learning framework is developed to optimize high‐throughput laser‐induced photothermal annealing of silicon suboxide anodes. By integrating probabilistic machine learning with empirical domain knowledge, this approach achieves optimal electrochemical performance using limited experiments.
Chaeyoung Park, Yeongje Lee, Sunho Jeong, Eungkyu Lee   +3 more
wiley   +1 more source

A Group Based Key Sharing and Management Algorithm for Vehicular Ad Hoc Networks

The Scientific World Journal, 2014
Vehicular ad hoc networks (VANETs) are one special type of ad hoc networks that involves vehicles on roads. Typically like ad hoc networks, broadcast approach is used for data dissemination.
Zeeshan Shafi Khan, Mohammed Morsi Moharram, Abdullah Alaraj, Farzana Azam   +3 more
doaj   +1 more source

Review Article: Problems and the Approaches of Machine Learning in Vehicle Ad Hoc Networks [PDF]

ITM Web of Conferences
In recent years, there has been a notable surge in research interest in vehicular ad-hoc networks (VANETs) due to advancements in wireless communication technology and the vehicle sector. Vehicles to vehicles (V2V) and vehicles to infrastructure comprise
Hussen Skala Hassan, Mohammed Marwan Aziz   +1 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source