Results 61 to 70 of about 4,485,992 (308)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Limits of predictability for large-scale urban vehicular mobility
, 2014 Key challenges in vehicular transportation and communication systems are understanding vehicular mobility and utilizing mobility prediction, which are vital for both solving the congestion problem and helping to build efficient vehicular communication ...
Chen, Sheng +4 more
core +1 more source
Information, 2017 With the unparalleled growth of motor vehicles, traffic accident between pedestrians and vehicles is one of the most serious issues in the word-wild. Plenty of injuries and fatalities are caused by the traffic accidents and crashes.
Peng Jing, Wei Huang, Long Chen
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Secure Multi-access Edge Computing Assisted Maneuver Control for Autonomous Vehicles
, 2021 The sensing capabilities of smart vehicles are growing and enabling unprecedented functionalities that drive the future commercial adoption of autonomous vehicles.
Tesei A. +3 more
core +1 more source
Resilient in-network aggregation for vehicular networks [PDF]
, 2015 Applications for vehicular ad hoc networks (VANETs) are an active field of re- search with the potential to significantly contribute to driver safety, traffic efficiency, and comfort. Messages are typically exchanged and forwarded between vehicles using wireless communication, thereby creating a wireless ad hoc network.
openaire +2 more sources
Scientific Reports, 2023 Vehicular Content Networks (VCNs) represent key empowering solution for content distribution in fully distributed manner for vehicular infotainment applications.
Divya Gupta +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Software-Defined Approach for Communication in Autonomous Transportation Systems
EAI Endorsed Transactions on Energy Web, 2017 Autonomous driving technology offers a promising solution to reduce road accidents, traffic congestion, and fuel consumption. The management of vehicular networks is challenging as it demands mobility, location awareness, high reliability and low latency
Piyush Dhawankar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source