Results 51 to 60 of about 835,120 (286)

Revisiting the impact of phenylephrine hydrochloride on static and dynamic accommodation

Indian Journal of Ophthalmology, 2012
Purpose: Phenylephrine hydrochloride (PHCl), a commonly used mydriatic agent, causes a small but significant deterioration of accommodation. The relative roles of pharmacology and optics in this deterioration, however, remain unascertained.
Samrat Sarkar, Ali Mohammed Hasnat, Shrikant R Bharadwaj   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Velocity

Sewanee Review
<p dir="ltr">Short film shot on iPad at Melbourne Central. It's about velocity and viscosity, how they might look the same, but feel oh so different. A short self-portrait.</p>
  +8 more sources

Correlação entre o desempenho de jogadores de futebol no teste de sprint de 30m e no teste de salto vertical Correlation between performance of Soccer players in the 30-meter sprint test and in the vertical jump test

Motriz: Revista de Educacao Fisica, 2011
O objetivo do estudo foi determinar o nível de correlação entre o desempenho nos 10m iniciais, dos 20m finais e no tempo total do teste de sprint de 30m, com o do salto vertical com contra-movimento (CMJ) entre jogadores de futebol.
Daniel Barbosa Coelho, Leonardo Gomes Martins Coelho, Mário Lucio Braga, Alexandre Paolucci, Christian Emmanuel Torres Cabido, João Batista Ferreira Junior, Thiago Teixeira Mendes, Luciano Sales Prado, Emerson Silami Garcia   +8 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Computerized Analysis of Flow Parameters for a Twin-Screw Compressor Using SolidWorks Flow Simulation

Computation
Twin-screw compressors (TSCs) are widely used in various industries. Their performance is influenced by several parameters, such as rotor profiles, clearance gaps, operating speed, and thermal effects. Traditionally, optimizing these parameters relied on
Ildiko Brinas, Florin Dumitru Popescu, Andrei Andras, Sorin Mihai Radu, Laura Cojanu   +4 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Roles of Ionic and Non-Ionic Osmolarities and Different pH Levels on Triggering Sperm Motility in Nile Tilapia (Oreochromis niloticus)

Turkish Journal of Agriculture: Food Science and Technology
Since advantageous properties such as fast growth rate, tolerance to severe water conditions, flesh quality, variations in feeding and high reproductive performances in different habitats, Nile tilapia (Oreochromis niloticus) become a popular cultured ...
Burak Evren İnanan
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source