Results 61 to 70 of about 108,996 (213)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analisis Komparasi Kinerja Bank Umum Syariah di Indonesia Menggunakan Maqashid Sharia Index

Velocity
Sektor perbankan syariah di Indonesia menunjukkan pertumbuhan yang signifikan, namun metode pengukuran kinerja yang selaras dengan prinsip-prinsip syariah masih menjadi isu krusial.
Noval Kurnia, Wartoyo, Syaeful Bakhri
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Research Study of Financial Literacy in Southeast Asia, Especially Indonesia and Malaysia: A Bibliometric Analysis

Velocity
This study aims to analyze trends, scientific contributions, and collaborations in financial literacy research in Southeast Asia using bibliometric methods. A total of 635 documents from the Scopus database, published between 2009 and 2024, were analyzed
Drajat Stiawan, Ahmad Rosyid, Retno Wahyuningsih, Vanessa Imeldalia   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Analisis Pengaruh Prinsip-Prinsip Tasawuf, Literasi Keuangan Syariah, dan Kualitas Pelayanan terhadap Keputusan Nasabah dalam Memilih Produk Perbankan Syariah

Velocity
Penelitian ini bertujuan untuk menganalisis pengaruh Prinsip-Prinsip Tasawuf, Literasi Keuangan Syariah, dan Kualitas Pelayanan terhadap Keputusan Nasabah dalam Memilih Produk Perbankan Syariah.
Hery Purwanto, Moh Sakir, Samsul Munir, Hendri Hermawan Adinugraha   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Influence of Leadership Style, Work Discipline and Compensation on Employee Performance in the Regional Government of Ogan Komering Ilir Regency

Velocity
This research aims to examine and analyze the influence of leadership style, work discipline and compensation on employee performance at the Regional Government Personnel, Education and Training Agency of Ogan Komering Ilir Regency.
Dany Supraja, Sulaiman Helmi, Heriyanto, Darwin   +3 more
doaj   +1 more source

“Speed” and “Velocity” [PDF]

Nature, 1885
SOME of your “general” readers, like myself, may wish to see the distinction between “velocity” and “speed” more easily defined than by a reference to the. calculus of quaternions, to which I believe the term “tensor” appertains.
openaire   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source