Results 71 to 80 of about 76,691 (283)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Seminal and spermatic characteristics of fresh semen and the effects of sperm cooling in Steindachneridion melanodermatum (Garavello, 2005)

Semina: Ciências Agrárias, 2015
This study describes the seminal and spermatic characteristics of fresh semen of Steindachneridion melanodermatum and investigates the effects of dilution, temperature, and storage period on its spermatic parameters.
Ronan Maciel Marcos, Giovano Neumann, Cesar Pereira Rebechi de Toledo, João Marcos Sena, Gilmar Baumgartner, Robie Allan Bombardelli   +5 more
doaj   +3 more sources

The Study of Numerical Simulation on the Effect of Potato Stacking Forms in Packaging Boxes on Storage Efficiency

Liang you shipin ke-ji
With the gradual use of packaging boxes for potato storage, the influence of different stacking methods on the storage effect of potatoes was studied.
ZHEN Qi, MA Lin-huan, TA Na, YAN Cai-xia, SUN Yun-feng, XU Chao   +5 more
doaj   +1 more source

EFFECT OF PRE-COOLING PROCESS ON SAFE STORAGE OF PEACH FRUITS STORED UNDER DIFFERENT STORAGE CONDITIONS [PDF]

Journal of Soil Sciences and Agricultural Engineering, 2010
A study was carried out to test and evaluate a portable pre-cooling unit. The effect of pre-cooling process on safe storage of the pre-cooled peach in comparison with the none cooled samples were also determined during storage process under two different
M. Sh. Radwan, H.E. Abd- Alla, M. M. El-Kholy   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A three-dimensional study of a crustal low velocity region beneath the 9°03′N overlapping spreading center

, 2003
Overlapping spreading centers (OSCs) play a key role in models of magma distribution at fast spreading ridges. To investigate the relationship between ridge-axis discontinuities and magma supply, we conducted a three-dimensional seismic reflection and ...
Harding, A.J., Pye, J, Kent, GM, Tong, CH, Tong, C.H., Sinha, MC, White, R.S., van Avendonk, H.J.A., Hobbs, R.W., Pye, J.W., Bazin, S, Harding, AJ, Barton, PJ, Hobbs, RW, Kent, G.M., Barton, P.J., Sinha, M.C., HJA, VA, Bazin, S., Orcutt, J.A., Singh, SC, Orcutt, JA, White, RS, Singh, S.C.   +23 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Ultrasound Velocity-Based Phase Content Measurement of Oil Sludge in Storage Tank

, 2021
Oil sludge presents a harmful but economically valuable waste. A large amount of oil sludge is produced during the processes of extraction, refining, storage, and transportation of petroleum.
Liu, Yanchu, Zhou, Hongliang, Ge, Xiaocheng, Jiang, Zhengjie   +3 more
core   +1 more source

Investigation of Ambient Factors Spatial Variability in Cold Stores by Using Management Zone Analysis

Journal of Agricultural Sciences, 2014
The main objective of this research was to determineand manage spatial variability of ambient temperature, relative humidity andair velocity in a cold storage using management zone analysis methods.  Ambient temperature, relative humidity and airvelocity
Serap Akdemir
doaj   +1 more source

Baclofen, motion sickness susceptibility and the neural basis for velocity storage

, 2008
Reduction of the dominant time constant (T(VOR)) of the angular vestibulo-ocular reflex (aVOR) by habituation is associated with a decrease in motion sickness susceptibility. Baclofen, a GABA(b) agonist, reduces the time constant of the velocity storage integrator in the aVOR in a dose-dependent manner.
Cohen, Bernard, Dai, Mingjia, Yakushin, Sergei B., Raphan, Theodore   +3 more
openaire   +3 more sources