Results 61 to 70 of about 269,913 (265)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Velocity structure tomography analysis in southern Hebei Province

地震科学进展
The destruction of cratons is one of the key research objects of geophysicists. According to China Earthquake Networks Center, small and medium-sized earthquakes have occurred more frequently in southern Hebei in recent years than before.
Shi Wang, Yi Zhou, Sisi Wang, Xiaolei Liu   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Velocity structure of the mantle and abyssal fluids of Southeast Asia

Геофизический журнал, 2012
The real work is devoted to consideration of velocity structure of mantle under SouthEast Asia with the purpose of possible selection of velocity mantle columns, communication of them with petroleumgas pools.
L. N. Zayets, Ding True Kao, T. A. Tsvetkova   +2 more
doaj   +1 more source

A Study on the Verification of Inlet Structural Improvement of Side Stream Typed Low Pressure Membrane Module Using PIV Method

대한환경공학회지, 2020
Objectives:The purposes of this study are to suggest a method to distribute the flow rate into the overall vessel vertically and evenly by improving the inlet hydraulic structure of the side stream type low pressure membrane module.
Minyoung Lee, Sukmin Yoon, Moon-Sun Kang, No-Suk Park   +3 more
doaj   +1 more source

Is There a Structural Break in Equilibrium Velocity in the Euro Area? [PDF]

SSRN Electronic Journal, 2007
We investigate the stability of M3 income velocity in the euro area. We apply a set of breakpoint procedures to examine this issue and conclude that at least one structural change occurred around 2000-2001. We also ...nd evidence of another structural break around 1992-1993.
Christian Bordes, Laurent Clerc, Vêlayoudom Marimoutou   +2 more
openaire   +3 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Upper mantle anisotropy and tectonic deformation beneath the Ordos Block in the western North China Craton: Constraints from wide-angle seismic data

Journal of Asian Earth Sciences: X, 2019
The Ordos Block is located in the northern part of the North China Craton and its interior is highly stable. A series of fault basins and faults has developed around the periphery, and seismic activity is frequent. To research the dynamic mechanisms that
Shuaijun Wang, Fuyun Wang, Xianghui Song, Baofeng Liu, Xiumin Bao, Zhanyong Gao   +5 more
doaj   +1 more source