Results 51 to 60 of about 269,913 (265)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Journal of Materials Research and Technology, 2020 The geometry of porous bone scaffolds has an important effect on its bone ingrowth, but there is still a lack of in-depth research on this aspect. This study establishes a curved structure and a strut structure with a porosity of 65% and a pore size of ...
Linlin Liu +5 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Petroleum Exploration and Development, 2017 The seismic imaging has three difficulties in the Keshen area of the Kuqa depression in Tarim Basin: difficult static correction, poor original data, difficult velocity modeling and pre-stack depth migration.
Qingcai ZENG +4 more
doaj +1 more source
Velocity structure in the Magellanic Stream
The Astronomical Journal, 1979 New high sensitivity neutral hydrogen observations of the area of the south galactic pole reveal that the region is littered with anomalous velocity clouds, both positive and negative. It is suggested that all of these clouds are associated with the Magellanic Stream phenomenon.
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Intensity, Velocity, and Magnetic Structure in and Around a Sunspot [PDF]
Symposium - International Astronomical Union, 1968 An observational study of the fine structure in a sunspot region led to the following results: (a) The photosphere around a sunspot is covered with the so-called Magnetic Knots. These features have a diameter of 800 km and a magnetic field of up to 1400 gauss.
J. M. Beckers, E.H. Schröter
openaire +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structure, Velocity Field, and Turbulence in NGC 604 [PDF]
The Astrophysical Journal, 1997 The Ha peak intensity, velocity shift and velocity dispersion maps of the giant HII region NGC 604 in M 33, obtained by two dimensional high spatial resolution Fabry-Perot observations with TAURUS II at the 4.2 m William Herschel Telescope in Spain (Sabalisck, 1995), are analyzed via two point correlation functions.
Tanco, G. A. Medina +3 more
openaire +2 more sources